| Gene Symbol |
BRAF
|
| Entrez Gene |
673
|
| Alt Symbol |
B-RAF1, BRAF1, NS7, RAFB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
B-Raf proto-oncogene, serine/threonine kinase
|
| Other Description |
94 kDa B-raf protein|B-Raf proto-oncogene serine/threonine-protein kinase (p94)|murine sarcoma viral (v-raf) oncogene homolog B1|proto-oncogene B-Raf|serine/threonine-protein kinase B-raf|v-raf murine sarcoma viral oncogene homolog B|v-raf murine sarcoma viral oncogene homolog B1
|
| Swissprots |
P15056 Q9UDP8 Q13878 Q9Y6T3 Q3MIN6 A4D1T4
|
| Accessions |
AAD15551 AAD43193 AAS00359 ACD11489 ADQ00186 ADX94397 AIE38317 CAA46301 CAZ68014 CBK51920 EAL24023 EAW83964 EAW83965 P15056 AA252358 AA834931 AI203435 AK054801 AK094023 AK098095 AK124257 AK314346 AW971583 BC038966 BC101757 AAI01758 BC112079 AAI12080 BM263585 DB454480 DN996440 HM437233 ADN43065 M21001 AAA96495 M95712 AAA35609 XM_005250045 XP_005250102 XM_005250046 XP_005250103 XM_011516529 XP_011514831 XM_011516530 XP_011514832 XR_242190 XR_927520 XR_927521 XR_927522 XR_927523 NM_004333 NP_004324
|
| Function |
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. {ECO:0000269|PubMed:21441910}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
|
| Tissue Specificity |
Brain and testis.
|
| Top Pathways |
Chemokine signaling pathway, Vascular smooth muscle contraction, Hepatitis C, Neurotrophin signaling pathway, Alcoholism
|