BRAF

Gene Symbol	BRAF
Entrez Gene	673
Alt Symbol	B-RAF1, BRAF1, NS7, RAFB1
Species	Human
Gene Type	protein-coding
Description	B-Raf proto-oncogene, serine/threonine kinase
Other Description	94 kDa B-raf protein|B-Raf proto-oncogene serine/threonine-protein kinase (p94)|murine sarcoma viral (v-raf) oncogene homolog B1|proto-oncogene B-Raf|serine/threonine-protein kinase B-raf|v-raf murine sarcoma viral oncogene homolog B|v-raf murine sarcoma viral oncogene homolog B1
Swissprots	P15056 Q9UDP8 Q13878 Q9Y6T3 Q3MIN6 A4D1T4
Accessions	AAD15551 AAD43193 AAS00359 ACD11489 ADQ00186 ADX94397 AIE38317 CAA46301 CAZ68014 CBK51920 EAL24023 EAW83964 EAW83965 P15056 AA252358 AA834931 AI203435 AK054801 AK094023 AK098095 AK124257 AK314346 AW971583 BC038966 BC101757 AAI01758 BC112079 AAI12080 BM263585 DB454480 DN996440 HM437233 ADN43065 M21001 AAA96495 M95712 AAA35609 XM_005250045 XP_005250102 XM_005250046 XP_005250103 XM_011516529 XP_011514831 XM_011516530 XP_011514832 XR_242190 XR_927520 XR_927521 XR_927522 XR_927523 NM_004333 NP_004324
Function	Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. {ECO:0000269|PubMed:21441910}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm. Cell membrane {ECO:0000250}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
Tissue Specificity	Brain and testis.
Top Pathways	Chemokine signaling pathway, Vascular smooth muscle contraction, Hepatitis C, Neurotrophin signaling pathway, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® B-Raf siRNA I - 8935 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® B-Raf siRNA II - 9439 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Raf-B CRISPR/Cas9 KO Plasmid (h) - sc-400121 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B HDR Plasmid (h) - sc-400121-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B Double Nickase Plasmid (h) - sc-400121-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B Double Nickase Plasmid (h2) - sc-400121-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B CRISPR Activation Plasmid (h) - sc-400121-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B CRISPR Activation Plasmid (h2) - sc-400121-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B Lentiviral Activation Particles (h) - sc-400121-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B Lentiviral Activation Particles (h2) - sc-400121-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Raf-B siRNA (h) - sc-36368 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Raf-B shRNA Plasmid (h) - sc-36368-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Raf-B shRNA (h) Lentiviral Particles - sc-36368-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

B-Raf RNAi - H00000673-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU127401 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0184 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0183 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0182 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2208 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2208 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01377 from Sigma-Aldrich Category miRNA

BRAF siRNA (Human) - CRH0468 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BRAF - MBS8203598 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BRAF shRNA Plasmid (Human) - CHH0468 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BRAF miRNA 3'UTR clone - MiUTR3H-01593 from Creative biogene Species Reactivities Human

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