| Gene Symbol |
DIAPH2
|
| Entrez Gene |
1730
|
| Alt Symbol |
DIA, DIA2, DRF2, POF, POF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diaphanous-related formin 2
|
| Other Description |
diaphanous homolog 2|diaphanous-related formin-2|diaphorase-2|protein diaphanous homolog 2
|
| Swissprots |
Q9UJL2 Q8WX48 A6NG19 O60878 O60879 Q8WX06
|
| Accessions |
CAJ42758 EAX02791 EAX02792 EAX02793 O60879 AK002029 BAG51003 AK291272 BAF83961 AW276516 BC117414 AAI17415 BC143838 AAI43839 BX363708 DB062196 U69179 Y15908 CAA75869 Y15909 CAA75870 NM_006729 NP_006720 NM_007309 NP_009293
|
| Function |
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}.
|
| Subcellular Location |
Isoform 3: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
|
| Tissue Specificity |
Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
|
| Top Pathways |
Regulation of actin cytoskeleton
|