COPS7B

Gene Symbol	COPS7B
Entrez Gene	64708
Alt Symbol	CSN7B, SGN7b
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 7B
Other Description	COP9 constitutive photomorphogenic homolog subunit 7B|COP9 signalosome complex subunit 7b|JAB1-containing signalosome subunit 7b|signalosome subunit 7b
Swissprots	Q9H9Q2 Q9H7V6 Q5BJG3 Q53S22
Accessions	AAY24152 CAE92117 EAW70979 EAW70980 EAW70981 EAW70982 Q9H9Q2 AA126041 AK022674 BAB14170 AK024273 BAB14868 AK098334 BAG53614 AK124133 BAG54013 AK126326 BAC86526 AK222879 BAD96599 AK307486 BC010739 AAH10739 BC091493 AAH91493 BE501968 BE504900 BI906506 BX333333 DA754035 HY051259 XM_006712692 XP_006712755 XM_006712693 XP_006712756 XM_011511638 XP_011509940 XM_011511639 XP_011509941 XM_011511640 XP_011509942 XM_011511641 XP_011509943 XM_011511642 XP_011509944 XM_011511643 XP_011509945 XR_922986 NM_001282949 NP_001269878 NM_001282950 NP_001269879 NM_001282951 NP_001269880 NM_001282952 NP_001269881 NM_001308381 NP_001295310 NM_022730 NP_073567
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
Subcellular Location	Cytoplasm. Nucleus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COPS7B 293T Cell Transient Overexpression Lysate(Denatured) - H00064708-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

COPS7B 293 Cell Lysate - 405805 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CSN7b Overexpression Lysate (Native) - NBP2-06417 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CSN7b (h2): 293T Lysate - sc-111513 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

COPS7B Over-expression Lysate Product - GWB-B7B3BA from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CSN7b Overexpression Lysate (Denatured) - H00064708-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

CSN7b Overexpression Lysate (Denatured) - H00064708-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human COPS7B Knockdown Stable Cell Line - CSC-DC003505 from Creative biogene Category Cell Line Species Human

COPS7B KO Cell Lysate-HEK293T - CLKO-0767 from Creative biogene Category Cell Lysate

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