COPS7B

Gene Symbol COPS7B
Entrez Gene 64708
Alt Symbol CSN7B, SGN7b
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 7B
Other Description COP9 constitutive photomorphogenic homolog subunit 7B|COP9 signalosome complex subunit 7b|JAB1-containing signalosome subunit 7b|signalosome subunit 7b
Swissprots Q9H9Q2 Q9H7V6 Q5BJG3 Q53S22
Accessions AAY24152 CAE92117 EAW70979 EAW70980 EAW70981 EAW70982 Q9H9Q2 AA126041 AK022674 BAB14170 AK024273 BAB14868 AK098334 BAG53614 AK124133 BAG54013 AK126326 BAC86526 AK222879 BAD96599 AK307486 BC010739 AAH10739 BC091493 AAH91493 BE501968 BE504900 BI906506 BX333333 DA754035 HY051259 XM_006712692 XP_006712755 XM_006712693 XP_006712756 XM_011511638 XP_011509940 XM_011511639 XP_011509941 XM_011511640 XP_011509942 XM_011511641 XP_011509943 XM_011511642 XP_011509944 XM_011511643 XP_011509945 XR_922986 NM_001282949 NP_001269878 NM_001282950 NP_001269879 NM_001282951 NP_001269880 NM_001282952 NP_001269881 NM_001308381 NP_001295310 NM_022730 NP_073567
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
Subcellular Location Cytoplasm. Nucleus.

CSN7b (N-16) - sc-47975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN7b (N-16): sc-47975. Western blot analysis of CSN7b expression in HeLa (A), HL-60 (B) and Jurkat (C) whole cell lysates, and HeLa (D) and HL-60 (E) nuclear extracts.

Anti-CSN7b antibody - ab89645 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-CSN7b antibody (ab89645) at 1 µg/ml + HeLa cell lysate at 50 µg

Anti-CSN7b antibody [EPR6464] - ab133548 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6464
All lanes : Anti-CSN7b antibody [EPR6464] (ab133548) at 1/10000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CSN7b antibody [EPR6465] - ab124718 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6465
All lanes : Anti-CSN7b antibody [EPR6465] (ab124718) at 1/10000 dilutionLane 1 : Jurkat cell lysatesLane 2 : HeLa cell lysatesLane 3 : HL60 cell lysatesLane 4 : HT-29 cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-COPS7B / CSN7b Antibody (C-Terminus) - LS-C63932 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPS7B / CSN7b Antibody - LS-C307814 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-COPS7B / CSN7b Antibody (C-Terminus) - LS-C287154 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human CSN7b by Western Blot. Samples: Whole cell lysate (50 ug - E; 10 ug - T) from HEK293T cells with (T) or without (E) with a CSN7b expression construct. Antibody: Affinity purified rabbit anti-CSN7b antibody used at the indicated concentrations. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-COPS7B / CSN7b Antibody (Internal, clone EPR6465) - LS-C138806 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR6465]
Immunofluorescent staining of HeLa cells using anti-CSN7B antibody.

Anti-COPS7B / CSN7b Antibody (C-Terminus) - LS-C286983 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human CSN7b by Western Blot. Samples: RIPA lysate (50 ug for E; 25 ug for T) from HEK293T cells that were mock transfected (E) or transfected with a CSN7b construct (T). Antibody: Affinity purified rabbit anti-CSN7B antibody used at the indicated concentration. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-COPS7B / CSN7b Antibody (Internal, clone EPR6464) - LS-C138836 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR6464]
IHC of paraffin-embedded human kidney tissue using anti- CSN7B antibody.

NCOA2 Antibody - NBP2-22162 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NCOA2 Antibody - hole cell lysate (50 ug) from TCMK-1, 4T1, and CT26.WT cells. Antibodies: Affinity purified rabbit anti-NCOA2 used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

CSN7b Antibody - NBP2-38214 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CSN7b Antibody [NBP2-38214] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

CSN7b Antibody - NBP1-85433 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CSN7b Antibody [NBP1-85433] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

CSN7b Antibody - H00064708-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CSN7b Antibody [H00064708-B01P] - Analysis of COPS7B expression in HeLa.

CSN7b Antibody - H00064708-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: CSN7b Antibody [H00064708-B01] - analysis of COPS7B expression in transfected 293T cell line by COPS7B MaxPab polyclonal antibody (B01). Lane 1: COPS7B transfected lysate (29.60 KDa). Lane 2: Non-transfected lysate.

CSN7b Antibody - NB100-461 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CSN7b Antibody [NB100-461] - Whole cell lysate (50 ug - E; 10 ug - T) from HEK293T cells with (T) or without (E) with a CSN7b expression construct. Antibody used at the indicated concentrations.

CSN7b Polyclonal Antibody - bs-11540R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11540R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11540R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11540R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11540R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, Cy3 Conjugated - bs-11540R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, Cy5 Conjugated - bs-11540R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, Cy5.5 Conjugated - bs-11540R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CSN7b Polyclonal Antibody, Cy7 Conjugated - bs-11540R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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