COPS7B

Gene Symbol COPS7B
Entrez Gene 64708
Alt Symbol CSN7B, SGN7b
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 7B
Other Description COP9 constitutive photomorphogenic homolog subunit 7B|COP9 signalosome complex subunit 7b|JAB1-containing signalosome subunit 7b|signalosome subunit 7b
Swissprots Q9H9Q2 Q9H7V6 Q5BJG3 Q53S22
Accessions AAY24152 CAE92117 EAW70979 EAW70980 EAW70981 EAW70982 Q9H9Q2 AA126041 AK022674 BAB14170 AK024273 BAB14868 AK098334 BAG53614 AK124133 BAG54013 AK126326 BAC86526 AK222879 BAD96599 AK307486 BC010739 AAH10739 BC091493 AAH91493 BE501968 BE504900 BI906506 BX333333 DA754035 HY051259 XM_006712692 XP_006712755 XM_006712693 XP_006712756 XM_011511638 XP_011509940 XM_011511639 XP_011509941 XM_011511640 XP_011509942 XM_011511641 XP_011509943 XM_011511642 XP_011509944 XM_011511643 XP_011509945 XR_922986 NM_001282949 NP_001269878 NM_001282950 NP_001269879 NM_001282951 NP_001269880 NM_001282952 NP_001269881 NM_001308381 NP_001295310 NM_022730 NP_073567
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
Subcellular Location Cytoplasm. Nucleus.

CSN7b CRISPR/Cas9 KO Plasmid (h) - sc-408275 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b HDR Plasmid (h) - sc-408275-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b Double Nickase Plasmid (h) - sc-408275-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b Double Nickase Plasmid (h2) - sc-408275-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b CRISPR Activation Plasmid (h) - sc-408275-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b CRISPR Activation Plasmid (h2) - sc-408275-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b Lentiviral Activation Particles (h) - sc-408275-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b Lentiviral Activation Particles (h2) - sc-408275-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CSN7b siRNA (h) - sc-60465 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN7b shRNA Plasmid (h) - sc-60465-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CSN7b shRNA (h) Lentiviral Particles - sc-60465-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU026181 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6438 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6438 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

COPS7B siRNA (Human) - CRJ2052 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS7B - MBS8216344 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COPS7B (NM_022730.1) - SHH267865 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COPS7B(NM_022730.1) - SHG192889 from Creative biogene

Category siRNA
Species Reactivities Human

Human COPS7B siRNA - orb272553 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COPS7B shRNA Plasmid (Human) - CHJ2052 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COPS7B miRNA 3'UTR clone - MiUTR1H-02361 from Creative biogene

Species Reactivities Human
Search more