| Gene Symbol |
NAAA
|
| Entrez Gene |
27163
|
| Alt Symbol |
ASAHL, PLT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acylethanolamine acid amidase
|
| Other Description |
ASAH-like protein|N-acylethanolamine-hydrolyzing acid amidase|acid ceramidase-like protein
|
| Swissprots |
Q96EY2 Q02083 Q5KTF2 Q9BRA8
|
| Accessions |
EAX05756 EAX05757 EAX05758 EAX05759 EAX05760 Q02083 AB161353 BAD88528 AK024677 AK301132 BAG62724 AK309271 AV723847 BC006388 AAH06388 BC011854 BM682921 BM763257 DR156596 M92449 AAA60119 W47597 XM_005262920 XP_005262977 XM_005262921 XP_005262978 XM_005262923 XP_005262980 XM_005262924 XP_005262981 XM_005262925 XP_005262982 XM_006714180 XP_006714243 XM_011531852 XP_011530154 XM_011531853 XP_011530155 XM_011531854 XP_011530156 NM_001042402 NP_001035861 NM_014435 NP_055250
|
| Function |
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine. {ECO:0000269|PubMed:15655246}.
|
| Subcellular Location |
Lysosome {ECO:0000305|PubMed:10610717, ECO:0000305|PubMed:15655246}.
|
| Tissue Specificity |
Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas. {ECO:0000269|PubMed:10610717}.
|
![Western Blot: ASAHL Overexpression Lysate (Adult Normal) [NBP2-10321] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ASAHL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1080_ASAHL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10321-img0001.jpg)