NAAA
| Gene Symbol | NAAA |
|---|---|
| Entrez Gene | 27163 |
| Alt Symbol | ASAHL, PLT |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-acylethanolamine acid amidase |
| Other Description | ASAH-like protein|N-acylethanolamine-hydrolyzing acid amidase|acid ceramidase-like protein |
| Swissprots | Q96EY2 Q02083 Q5KTF2 Q9BRA8 |
| Accessions | EAX05756 EAX05757 EAX05758 EAX05759 EAX05760 Q02083 AB161353 BAD88528 AK024677 AK301132 BAG62724 AK309271 AV723847 BC006388 AAH06388 BC011854 BM682921 BM763257 DR156596 M92449 AAA60119 W47597 XM_005262920 XP_005262977 XM_005262921 XP_005262978 XM_005262923 XP_005262980 XM_005262924 XP_005262981 XM_005262925 XP_005262982 XM_006714180 XP_006714243 XM_011531852 XP_011530154 XM_011531853 XP_011530155 XM_011531854 XP_011530156 NM_001042402 NP_001035861 NM_014435 NP_055250 |
| Function | Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine. {ECO:0000269|PubMed:15655246}. |
| Subcellular Location | Lysosome {ECO:0000305|PubMed:10610717, ECO:0000305|PubMed:15655246}. |
| Tissue Specificity | Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas. {ECO:0000269|PubMed:10610717}. |
ASAHL CRISPR/Cas9 KO Plasmid (h) - sc-407543 from Santa Cruz Biotechnology
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ASAHL HDR Plasmid (h) - sc-407543-HDR from Santa Cruz Biotechnology
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ASAHL Double Nickase Plasmid (h) - sc-407543-NIC from Santa Cruz Biotechnology
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ASAHL Double Nickase Plasmid (h2) - sc-407543-NIC-2 from Santa Cruz Biotechnology
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ASAHL CRISPR Activation Plasmid (h) - sc-407543-ACT from Santa Cruz Biotechnology
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ASAHL CRISPR Activation Plasmid (h2) - sc-407543-ACT-2 from Santa Cruz Biotechnology
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ASAHL Lentiviral Activation Particles (h) - sc-407543-LAC from Santa Cruz Biotechnology
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ASAHL Lentiviral Activation Particles (h2) - sc-407543-LAC-2 from Santa Cruz Biotechnology
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ASAHL siRNA (h) - sc-88929 from Santa Cruz Biotechnology
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ASAHL shRNA Plasmid (h) - sc-88929-SH from Santa Cruz Biotechnology
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ASAHL shRNA (h) Lentiviral Particles - sc-88929-V from Santa Cruz Biotechnology
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ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase RNAi - H00027163-R02 from Novus Biologicals
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ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase RNAi - H00027163-R01 from Novus Biologicals
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MISSION® esiRNA - EHU012391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14914 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14914 from Sigma-Aldrich
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NAAA siRNA (Human) - CRH9003 from Cohesion Biosciences
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ASAHL CRISPR/Cas9 KO Plasmid (h2) - sc-407543-KO-2 from Santa Cruz Biotechnology
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ASAHL HDR Plasmid (h2) - sc-407543-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NAAA (NM_014435.3) - SHH348840 from Creative biogene
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shRNA set against Human ASAHL(NM_001042402.1) - SHG075877 from Creative biogene
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shRNA set against Human ASAHL(NM_014435.3) - SHG075913 from Creative biogene
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Human NAAA siRNA - orb269505 from Biorbyt
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NAAA shRNA Plasmid (Human) - CHH9003 from Cohesion Biosciences
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NAAA miRNA 3'UTR clone - MiUTR1H-00619 from Creative biogene
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