| Gene Symbol | TDG |
|---|---|
| Entrez Gene | 6996 |
| Alt Symbol | hTDG |
| Species | Human |
| Gene Type | protein-coding |
| Description | thymine-DNA glycosylase |
| Other Description | G/T mismatch-specific thymine DNA glycosylase |
| Swissprots | Q8IUZ6 Q13569 Q8IZM3 |
| Accessions | AAN16399 EAW97727 EAW97728 EAW97729 Q13569 AI004247 AI452763 AK295387 BAG58341 AK299832 BAG61699 AK303631 BAG64639 AK309792 AK311673 AK313234 BAG36045 AL710869 BC001307 BC010945 BC019925 AAH19925 BC037557 AAH37557 BC071714 BC104477 AAI04478 CB047650 CN274338 DB162106 DN601672 DQ786320 XM_005269125 XP_005269182 XM_011538714 XP_011537016 XM_011538715 XP_011537017 XR_429113 NM_003211 NP_003202 NM_001008411 |
| Function | DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition t |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:8662714}. |
| Top Pathways | Base excision repair |