TDG

Gene Symbol	TDG
Entrez Gene	6996
Alt Symbol	hTDG
Species	Human
Gene Type	protein-coding
Description	thymine-DNA glycosylase
Other Description	G/T mismatch-specific thymine DNA glycosylase
Swissprots	Q8IUZ6 Q13569 Q8IZM3
Accessions	AAN16399 EAW97727 EAW97728 EAW97729 Q13569 AI004247 AI452763 AK295387 BAG58341 AK299832 BAG61699 AK303631 BAG64639 AK309792 AK311673 AK313234 BAG36045 AL710869 BC001307 BC010945 BC019925 AAH19925 BC037557 AAH37557 BC071714 BC104477 AAI04478 CB047650 CN274338 DB162106 DN601672 DQ786320 XM_005269125 XP_005269182 XM_011538714 XP_011537016 XM_011538715 XP_011537017 XR_429113 NM_003211 NP_003202 NM_001008411
Function	DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition t
Subcellular Location	Nucleus {ECO:0000269|PubMed:8662714}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Thymine DNA glycosylase full length protein - ab114876 from Abcam Category Protein Source Wheat germ Species Human

Human Thymine DNA glycosylase full length protein - ab134525 from Abcam Category Protein Source E. coli Species Human

Human Thymine DNA glycosylase peptide - ab46741 from Abcam Category Peptide

TDG / Thymine DNA Glycosylase Antibody Blocking Peptide - LS-E8336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDG / Thymine DNA Glycosylase Antibody Blocking Peptide - LS-E8337 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDG Partial Recombinant Protein - H00006996-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TDG Recombinant Protein - H00006996-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human TDG Protein - NBP2-22863 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

TDG-Antibody-C-term-Blocking-Peptide - BP6624b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TDG-Antibody-N-term-Blocking-Peptide - BP6624a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TDG protein - orb169407 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Thymine DNA Glycosylase Peptide - orb224220 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

TDG protein (His tag) - 80R-2457 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

TDG (1-410, His-tag) - AR50529PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

TDG (1-410, His-tag) - AR50529PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

TDG - H00006996-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

TDG - H00006996-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

TDG - H00006996-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

TDG - H00006996-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TDG - H00006996-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TDG, 1-410aa, Human, His tag, E.coli - 01-P1705 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

TDG fusion protein - ag4190 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TDG Human - ENPS-656 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

TDG, 1-410aa, Recombinant Protein - GWB-P0333H from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Thymine-DNA Glycosylase, His-tagged - TDG-7134H from Creative Biomart Category Protein Source E. coli Species Human

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