TDG

Gene Symbol	TDG
Entrez Gene	6996
Alt Symbol	hTDG
Species	Human
Gene Type	protein-coding
Description	thymine-DNA glycosylase
Other Description	G/T mismatch-specific thymine DNA glycosylase
Swissprots	Q8IUZ6 Q13569 Q8IZM3
Accessions	AAN16399 EAW97727 EAW97728 EAW97729 Q13569 AI004247 AI452763 AK295387 BAG58341 AK299832 BAG61699 AK303631 BAG64639 AK309792 AK311673 AK313234 BAG36045 AL710869 BC001307 BC010945 BC019925 AAH19925 BC037557 AAH37557 BC071714 BC104477 AAI04478 CB047650 CN274338 DB162106 DN601672 DQ786320 XM_005269125 XP_005269182 XM_011538714 XP_011537016 XM_011538715 XP_011537017 XR_429113 NM_003211 NP_003202 NM_001008411
Function	DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition t
Subcellular Location	Nucleus {ECO:0000269|PubMed:8662714}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TDG-Over-expression-Lysate - LY11502a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

TDG 293T Cell Transient Overexpression Lysate(Denatured) - H00006996-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TDG 293 Cell Lysate - 401034 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TDG Overexpression Lysate (Denatured) - H00006996-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TDG Overexpression Lysate (Native) - NBL1-16797 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TDG Over-expression Lysate Product - GWB-6A3321 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human TDG Knockdown Stable Cell Line - CSC-DC015755 from Creative biogene Category Cell Line Species Human

Human TDG Knockout Cell Line-HeLa - CSC-RT1657 from Creative biogene Category Cell Line Species Human

TDG KO Cell Lysate-HeLa - CLKO-1504 from Creative biogene Category Cell Lysate

TDG KO Cell Lysate-HeLa - CLKO-1718 from Creative biogene Category Cell Lysate

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