SHH

Gene Symbol	SHH
Entrez Gene	6469
Alt Symbol	HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
Species	Human
Gene Type	protein-coding
Description	sonic hedgehog
Other Description	sonic hedgehog homolog|sonic hedgehog protein
Swissprots	A4D247 Q15465 Q75MC9
Accessions	AAB67604 AAQ87879 AAS01990 ADL14518 BAA34689 EAL23913 EAX04543 Q15465 AY927450 AY927451 AY927452 AY927453 AY927455 BC111925 AAI11926 L38518 AAA62179 XM_011516479 XP_011514781 XM_011516480 XP_011514782 XM_011516481 XP_011514783 XM_011516482 XP_011514784 NM_000193 NP_000184
Function	Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). {ECO:0000250}.
Subcellular Location	Sonic hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
Tissue Specificity	Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
Top Pathways	Hedgehog signaling pathway, Basal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Sonic Hedgehog Human ELISA Kit - ab100639 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 20 pg/ml Range 13.72 pg/ml - 10000 pg/ml

Human ShhN ELISA Kit - RAB0430 from Sigma-Aldrich Category ELISA Kit

Human SHH / Sonic Hedgehog ELISA Kit (Sandwich ELISA) - LS-F5010 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 27 pg/ml Range 42-10000 pg/ml

Rat SHH / Sonic Hedgehog ELISA Kit (Sandwich ELISA) - LS-F7213 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.59 ng/ml Range 42-10000 pg/ml

Human SHH / Sonic Hedgehog ELISA Kit (Sandwich ELISA) - LS-F477 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 42 pg/ml Range 42-10000 pg/ml

Mouse SHH / Sonic Hedgehog ELISA Kit (Sandwich ELISA) - LS-F509 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4.096 pg/ml Range 42-10000 pg/ml

Mouse Sonic Hedgehog/Shh N-Terminus Quantikine ELISA Kit - MSHH00 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 2.37 pg/mL Range 7.8 - 500 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma)

Mouse Sonic Hedgehog/Shh DuoSet ELISA - DY461 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

Hedgehog Homolog, Sonic (SHH), Human, ELISA Kit - SEB831Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 31pg/mL Range 78-5,000pg/mL

Hedgehog Homolog, Sonic, SHH, Human, ELISA Kit - E-EL-H0930 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Sonic hedgehog protein, SHH, Human, ELISA Kit - E1831h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 15.6-1000 pg/mL

Sonic hedgehog, Human, ELISA Kit - CSB-E12005h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 15.6 pg/ml Range 62.5 pg/ml-4000 pg/ml

Hedgehog Homolog, Sonic, SHH, Mouse, ELISA Kit - E-EL-M0623 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Hedgehog Homolog, Sonic, SHH, Rat, ELISA Kit - E-EL-R0484 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Hedgehog Homolog, Sonic, SHH, Rabbit, ELISA Kit - E-EL-RB0342 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SHH (Hedgehog Homolog, Sonic), Chicken, ELISA Kit - E-EL-Ch1088 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Hedgehog Homolog, Sonic, SHH, Porcine, ELISA Kit - E-EL-P2226 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Hedgehog Homolog, Sonic, SHH, Monkey, ELISA Kit - E-EL-MK1834 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SHH (N-terminal) (Human) ELISA Kit - KA2144 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human ShhN ELISA - ELH-ShhN from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 42 pg/ml in Assay Diluent C, and 8 pg/ml in Assay Diluent B. Range 8 pg/ml - 10000 pg/ml

Human SHH ELISA Kit - HS0111 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine SHH ELISA Kit - AS0111 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

SHH, ELISA Kit - MBS2511994 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human SHH is 46.875pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 78.125-5000pg/mL

SHH (N-terminal) (Human) ELISA Kit - DEIA4201 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of Shh-N is typically less than 42 pg/mL in Assay Diluent C and 8 pg/mL in Assay Diluent B respectivelly.

Human SHH(Hedgehog Homolog, Sonic) ELISA Kit - E-EL-H0930 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

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