SHH

Gene Symbol	SHH
Entrez Gene	6469
Alt Symbol	HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
Species	Human
Gene Type	protein-coding
Description	sonic hedgehog
Other Description	sonic hedgehog homolog|sonic hedgehog protein
Swissprots	A4D247 Q15465 Q75MC9
Accessions	AAB67604 AAQ87879 AAS01990 ADL14518 BAA34689 EAL23913 EAX04543 Q15465 AY927450 AY927451 AY927452 AY927453 AY927455 BC111925 AAI11926 L38518 AAA62179 XM_011516479 XP_011514781 XM_011516480 XP_011514782 XM_011516481 XP_011514783 XM_011516482 XP_011514784 NM_000193 NP_000184
Function	Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). {ECO:0000250}.
Subcellular Location	Sonic hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
Tissue Specificity	Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
Top Pathways	Hedgehog signaling pathway, Basal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Sonic Hedgehog full length protein - ab82127 from Abcam Category Protein Prices $110.00, $316.00 Sizes 5 µg, 25 µg Source E. coli Species Human

Active human Sonic Hedgehog protein fragment - ab123773 from Abcam Category Protein Prices $302.00 Sizes 25 µg Source E. coli Species Human

Active human Sonic Hedgehog protein fragment - ab174054 from Abcam Category Protein Prices $279.00 Sizes 50 µg Source HEK 293 cells Species Human

Active mouse Sonic Hedgehog protein fragment - ab75431 from Abcam Category Protein Prices $257.00 Sizes 5 µg Source E. coli Species Mouse

Human Sonic Hedgehog peptide - ab21448 from Abcam Category Peptide

Human Sonic Hedgehog protein fragment - ab151944 from Abcam Category Protein Source E. coli Species Human

Mouse Sonic Hedgehog protein fragment - ab95307 from Abcam Category Protein Source E. coli Species Mouse

Sonic Hedgehog peptide - ab203144 from Abcam Category Peptide

Human Sonic Hedgehog/Shh Protein - NBP2-35265 from Novus Biologicals Category Protein Prices $75.00 Sizes 5 µg Source Escherichia coli. Species Human

Sonic Hedgehog/Shh Partial Recombinant Protein - H00006469-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Sonic Hedgehog/Shh Protein - NBP1-44461 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

Sonic Hedgehog/Shh Protein - NBP1-44495 from Novus Biologicals Category Protein Species Human

Sonic Hedgehog/Shh Recombinant Protein - P4440 from Novus Biologicals Category Protein Prices $379.00 Sizes 25 µg Species Human

Sonic Hedgehog/Shh Protein - NBP1-99301 from Novus Biologicals Category Protein Species Human

Recombinant Human Sonic Hedgehog/Shh Protein - NBP1-99690 from Novus Biologicals Category Protein Prices $595.00 Sizes 100 µg Source E. coli Species Human

Sonic Hedgehog/Shh Recombinant Protein - P3553 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

SHH-Antibody-Center-Blocking-peptide - BP12343c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHH-Antibody-Center-Blocking-peptide - BP5844c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Shh Recombinant Protein (Active) - GTX48138-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

SIAH1 blocking peptide - GTX89950-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus - 1845-SH-025 from R&D Systems Category Protein Source E. coli-derived, Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus - 1845-SH-100 from R&D Systems Category Protein Source E. coli-derived, Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus - 1845-SH-500 from R&D Systems Category Protein Source E. coli-derived, Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus, CF - 1845-SH-025/CF from R&D Systems Category Protein Source E. coli-derived, Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met

Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus, CF - 1845-SH-100/CF from R&D Systems Category Protein Source E. coli-derived, Cys24-Gly197 (Cys24Ile-Ile), with an N-terminal Met

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