| Gene Symbol | SART1 |
|---|---|
| Entrez Gene | 9092 |
| Alt Symbol | Ara1, HOMS1, SART1259, SNRNP110, Snu66 |
| Species | Human |
| Gene Type | protein-coding |
| Description | squamous cell carcinoma antigen recognized by T cells |
| Other Description | IgE autoantigen|SART-1|SART1(259) protein|SART1(800) protein|SNU66 homolog|U4/U6.U5 tri-snRNP-associated 110 kDa protein|U4/U6.U5 tri-snRNP-associated protein 1|hSART-1|hSnu66|small nuclear ribonucleoprotein 110kDa (U4/U6.U5)|squamous cell carcinoma antigen recognised by T cells|squamous cell carcinoma antigen recognized by T cells 1|squamous cell carcinoma antigen recognized by T-cells 1 |
| Swissprots | O43290 Q53GB5 A6NDN1 |
| Accessions | AAD20223 EAW74474 EAW74475 O43290 AB006198 BAA24056 AF353625 AAK49523 AK223016 BAD96736 AK293200 BAG56740 AK297589 BAG59976 AK298184 BAG60455 AK309104 AU136920 AW082868 BC001058 AAH01058 BC018607 BM668558 BM693243 BT006637 AAP35283 BX648500 DQ891694 ABM82620 EU176645 ABW03446 Y14314 CAA74694 XM_011545344 XP_011543646 XM_011545345 XP_011543647 XR_950099 NM_005146 NP_005137 |
| Function | Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269|PubMed:11350945}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11350945, ECO:0000269|PubMed:9449708}. Note=Found in the nucleus of mitogen- activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:9449708}. |
| Top Pathways | Spliceosome |
SART-1 CRISPR/Cas9 KO Plasmid (h) - sc-404297 from Santa Cruz Biotechnology
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SART-1 HDR Plasmid (h) - sc-404297-HDR from Santa Cruz Biotechnology
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SART-1 Double Nickase Plasmid (h) - sc-404297-NIC from Santa Cruz Biotechnology
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SART-1 Double Nickase Plasmid (h2) - sc-404297-NIC-2 from Santa Cruz Biotechnology
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SART-1 CRISPR Activation Plasmid (h) - sc-404297-ACT from Santa Cruz Biotechnology
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SART-1 CRISPR Activation Plasmid (h2) - sc-404297-ACT-2 from Santa Cruz Biotechnology
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SART-1 Lentiviral Activation Particles (h) - sc-404297-LAC from Santa Cruz Biotechnology
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SART-1 Lentiviral Activation Particles (h2) - sc-404297-LAC-2 from Santa Cruz Biotechnology
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SART-1 siRNA (h) - sc-62978 from Santa Cruz Biotechnology
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SART-1 shRNA Plasmid (h) - sc-62978-SH from Santa Cruz Biotechnology
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SART-1 shRNA (h) Lentiviral Particles - sc-62978-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18855 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18855 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08170 from Sigma-Aldrich
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SART1 siRNA (Human) - CRH6005 from Cohesion Biosciences
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SART1 - MBS8207914 from MyBioSource
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shRNA set against Human SART1 (NM_005146.4) - SHH401940 from Creative biogene
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shRNA set against Human SART1(NM_005146.4) - SHR205392 from Creative biogene
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SART1 shRNA Plasmid (Human) - CHH6005 from Cohesion Biosciences
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SART1 miRNA 3'UTR clone - MiUTR1H-09139 from Creative biogene
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