| Gene Symbol |
CCL3
|
| Entrez Gene |
6348
|
| Alt Symbol |
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 3
|
| Other Description |
C-C motif chemokine 3|G0/G1 switch regulatory protein 19-1|PAT 464.1|SIS-beta|macrophage inflammatory protein 1-alpha|small inducible cytokine A3 (homologous to mouse Mip-1a)|tonsillar lymphocyte LD78 alpha protein
|
| Swissprots |
P10147
|
| Accessions |
AAA35858 AAB47170 ABK41952 BAA14172 CAA27643 EAW80100 P10147 AF043339 AAC03539 BC071834 AAH71834 BC171831 AAI71831 BC171891 AAI71891 BX103455 D00044 BAA00029 D63785 BAA09855 M23452 AAA36316 M25315 AAA57255 X03754 CAA27388 NM_002983 NP_002974
|
| Function |
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Chemokine signaling pathway, Chagas disease (American trypanosomiasis), Rheumatoid arthritis
|
