Gene Symbol | CCL3 |
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Entrez Gene | 6348 |
Alt Symbol | G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 3 |
Other Description | C-C motif chemokine 3|G0/G1 switch regulatory protein 19-1|PAT 464.1|SIS-beta|macrophage inflammatory protein 1-alpha|small inducible cytokine A3 (homologous to mouse Mip-1a)|tonsillar lymphocyte LD78 alpha protein |
Swissprots | P10147 |
Accessions | AAA35858 AAB47170 ABK41952 BAA14172 CAA27643 EAW80100 P10147 AF043339 AAC03539 BC071834 AAH71834 BC171831 AAI71831 BC171891 AAI71891 BX103455 D00044 BAA00029 D63785 BAA09855 M23452 AAA36316 M25315 AAA57255 X03754 CAA27388 NM_002983 NP_002974 |
Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Chemokine signaling pathway, Chagas disease (American trypanosomiasis), Rheumatoid arthritis |
MIP-1α CRISPR/Cas9 KO Plasmid (h) - sc-416660 from Santa Cruz Biotechnology
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MIP-1α HDR Plasmid (h) - sc-416660-HDR from Santa Cruz Biotechnology
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MIP-1α Double Nickase Plasmid (h) - sc-416660-NIC from Santa Cruz Biotechnology
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MIP-1α Double Nickase Plasmid (h2) - sc-416660-NIC-2 from Santa Cruz Biotechnology
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MIP-1α CRISPR Activation Plasmid (h) - sc-416660-ACT from Santa Cruz Biotechnology
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MIP-1α CRISPR Activation Plasmid (h2) - sc-416660-ACT-2 from Santa Cruz Biotechnology
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MIP-1α Lentiviral Activation Particles (h) - sc-416660-LAC from Santa Cruz Biotechnology
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MIP-1α Lentiviral Activation Particles (h2) - sc-416660-LAC-2 from Santa Cruz Biotechnology
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MIP-1α siRNA (h) - sc-43933 from Santa Cruz Biotechnology
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MIP-1α shRNA Plasmid (h) - sc-43933-SH from Santa Cruz Biotechnology
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MIP-1α shRNA (h) Lentiviral Particles - sc-43933-V from Santa Cruz Biotechnology
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Macrophage Inflammatory Protein 1 alpha RNAi - H00006348-R01 from Novus Biologicals
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MISSION® esiRNA - EHU115051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5615 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5615 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03220 from Sigma-Aldrich
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CCL3 siRNA (Human) - CRH4283 from Cohesion Biosciences
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CCL3 - MBS8214312 from MyBioSource
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shRNA set against Human CCL3 (NM_002983.2) - SHH257657 from Creative biogene
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shRNA set against Human CCL3(NM_002983.2) - SHG151207 from Creative biogene
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CCL3 shRNA Plasmid (Human) - CHH4283 from Cohesion Biosciences
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CCL3 miRNA 3'UTR clone - MiUTR3H-02106 from Creative biogene
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