Gene Symbol |
MTBP
|
Entrez Gene |
27085
|
Alt Symbol |
MDM2BP
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
MDM2 binding protein
|
Other Description |
MDM2 (mouse double minute 2)-binding protein, 104kD|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa|mdm2-binding protein
|
Swissprots |
Q96DY7 Q9HA89 B4DUR5
|
Accessions |
EAW92006 EAW92007 Q96DY7 AK022122 BAB13965 AK300762 BAG62427 AL832671 BC013136 AAH13136 EU176294 ABW03745 EU176618 ABW03419 XM_011516962 XP_011515264 XM_011516963 XP_011515265 XR_928318 NM_022045 NP_071328
|
Function |
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. {ECO:0000250, ECO:0000269|PubMed:15632057}.
|