| Gene Symbol |
NELFE
|
| Entrez Gene |
7936
|
| Alt Symbol |
D6S45, NELF-E, RD, RDBP, RDP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative elongation factor complex member E
|
| Other Description |
RD RNA binding protein|RD RNA-binding protein|RNA-binding protein RD|major histocompatibility complex gene RD|negative elongation factor E|negative elongation factor polypeptide E|nuclear protein
|
| Swissprots |
Q96F56 Q5JP74 P18615 B4DUN1 A2BE08 B4DYX9 Q5JP75 Q9NPK2
|
| Accessions |
AAA36308 AAB67979 AAK29466 CAB89308 EAX03551 EAX03552 EAX03553 P18615 AK300717 BAG62393 AK300898 BAH13370 AK302652 BAG63891 AK303152 BAG64255 BC025235 AAH25235 BC050617 AAH50617 BU935034 CD579634 DQ896847 ABM87846 JQ313904 AFH41798 L03411 AAC37523 X16105 CAA34231 XM_006715205 XP_006715268 XM_006725521 XP_006725584 XM_006725739 XP_006725802 XM_006725936 XP_006725999 XM_006726037 XP_006726100 XM_006726125 XP_006726188 XM_011514913 XP_011513215 XM_011547314 XP_011545616 XM_011547716 XP_011546018 XM_011548102 XP_011546404 XM_011548301 XP_011546603 XM_011548486 XP_011546788 NM_002904 NP_002895
|
| Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11940650, ECO:0000269|PubMed:12612062}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:12612062}.
|