| Gene Symbol | PDGFRA |
|---|---|
| Entrez Gene | 5156 |
| Alt Symbol | CD140A, PDGFR-2, PDGFR2, RHEPDGFRA |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet-derived growth factor receptor, alpha polypeptide |
| Other Description | CD140 antigen-like family member A|CD140a antigen|PDGF-R-alpha|PDGFRA/BCR fusion|alpha-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 2|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein |
| Swissprots | E9PBH0 P16234 B2RE69 Q96KZ7 Q6P4H5 Q9UD28 |
| Accessions | BAA08742 CAJ33669 CAJ33686 CAN37625 CBH30545 EAX05457 EAX05458 P16234 AA599881 AA625689 AK308353 AK311006 AK316578 BAG38166 AV689272 BC015186 AAH15186 BC063414 AAH63414 DA678599 L25829 M21574 AAA96715 M22734 AAA60048 M30494 X76079 XM_005265743 XP_005265800 XM_006714039 XP_006714102 XM_006714041 XP_006714104 XM_011534385 XP_011532687 XM_011534386 XP_011532688 NM_006206 NP_006197 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single- pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Note=The activated receptor is rapidly internalized and degraded. |
| Tissue Specificity | Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. {ECO:0000269|PubMed:2536956, ECO:0000269|PubMed:7896447, ECO:0000269|PubMed:8188664}. |
| Top Pathways | Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Choline metabolism in cancer |