PDGFRA

Gene Symbol PDGFRA
Entrez Gene 5156
Alt Symbol CD140A, PDGFR-2, PDGFR2, RHEPDGFRA
Species Human
Gene Type protein-coding
Description platelet-derived growth factor receptor, alpha polypeptide
Other Description CD140 antigen-like family member A|CD140a antigen|PDGF-R-alpha|PDGFRA/BCR fusion|alpha-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 2|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Swissprots E9PBH0 P16234 B2RE69 Q96KZ7 Q6P4H5 Q9UD28
Accessions BAA08742 CAJ33669 CAJ33686 CAN37625 CBH30545 EAX05457 EAX05458 P16234 AA599881 AA625689 AK308353 AK311006 AK316578 BAG38166 AV689272 BC015186 AAH15186 BC063414 AAH63414 DA678599 L25829 M21574 AAA96715 M22734 AAA60048 M30494 X76079 XM_005265743 XP_005265800 XM_006714039 XP_006714102 XM_006714041 XP_006714104 XM_011534385 XP_011532687 XM_011534386 XP_011532688 NM_006206 NP_006197
Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever
Subcellular Location Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single- pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Note=The activated receptor is rapidly internalized and degraded.
Tissue Specificity Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. {ECO:0000269|PubMed:2536956, ECO:0000269|PubMed:7896447, ECO:0000269|PubMed:8188664}.
Top Pathways Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Choline metabolism in cancer

PathScan ® Phospho-PDGF Receptor α/β (panTyr) Sandwich ELISA Kit - 7235 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-PDGF Receptor α (Tyr849) Sandwich ELISA Kit - 7296 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-PDGF Receptor α (Tyr849) Sandwich ELISA Antibody Pair - 7317 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)
The relationship between protein concentration of untreated and PDGF-treated MG63 cell lysates and the absorbance at 450 nm is shown. Cells were serum starved overnight and then treated with PDGF (50 ng/ml) for 7 min. at 37oC.

PathScan® Total PDGF Receptor α Sandwich ELISA Kit - 7318 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-PDGF Receptor α/β (panTyr) Sandwich ELISA Antibody Pair - 7307 from Cell Signaling Technology

Category Antibody Pair

PathScan ® Total PDGF Receptor α Sandwich ELISA Antibody Pair - 7264 from Cell Signaling Technology

Category Antibody Pair

HTScan ® PDGF Receptor alpha Kinase Assay Kit - 7767 from Cell Signaling Technology

Category Assay Kit
Figure 4. PDGFR alpha kinase activity was measured in a radioisotopic filtration assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 uM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 ug/50 ul PEG20.000, Substrate: Poly(AEKY) 2.5 ug/50 ul, Recombinant PDGFR alpha: 20 Units/50 ul.

HTScan® Mouse PDGF Receptor α Kinase Assay Kit - 7919 from Cell Signaling Technology

Category Assay Kit
Figure 1. Mouse PDGFRalpha kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 100 µM ATP, 250 µM FLT3 (Tyr589) biotinylated peptide and variable amount of Recombinant mouse PDGFRalpha. Reaction mixture incubated at room temperature for 10 minutes.

HTScan® PDGF Receptor α D842V Kinase Assay Kit - 7915 from Cell Signaling Technology

Category Assay Kit
Figure 1. PDGFRalpha D842V kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 100 µM ATP, 100 µM FLT3 (Tyr589) Biotinylated Peptide (#1305) and variable amount of Recombinant PDGFRalpha D842V. Reaction mixture incubated at room temperature for 10 minutes.

HTScan® PDGF Receptor α Kinase Assay Kit - 7913 from Cell Signaling Technology

Category Assay Kit
Figure 1. PDGFRalpha kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, 100 µM ATP, 100 µM FLT3 (Tyr589) Biotinylated Peptide (#1305) and variable amount of Recombinant PDGFRalpha. Reaction mixture incubated at room temperature for 10 minutes.

PDGF R-alpha (CD140) Human ELISA Kit - ab155438 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Sensitivity < 0.4 ng/ml
Range 0.49 ng/ml - 120 ng/ml
Representative standard curve using ab155438 - Assay Diluent C.

Rat PDGFRA / PDGFR Alpha ELISA Kit (Sandwich ELISA) - LS-F5984 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.056 ng/ml
Range 0.492-48 ng/ml

Human PDGFRA / PDGFR Alpha ELISA Kit (Sandwich ELISA) - LS-F5865 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.492-48 ng/ml

Mouse/Human/Rat Phospho-PDGFRA / PDGFR Alpha (Tyr849) Cell-Based ELISA Kit - LS-F1705 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human Phospho-PDGFRA / PDGFR Alpha (Tyr713) Cell-Based ELISA Kit - LS-F1207 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human PDGFRA / PDGFR Alpha ELISA Kit (Cell-Based ELISA) - LS-F2232 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.492-48 ng/ml

Phosphotyrosine PDGFRA / Platelet-derived Growth Factor Receptor Alpha ELISA Kit - RAB0984 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Human PDGF R α  ELISA Kit - RAB0399 from Sigma-Aldrich

Category ELISA Kit
Prices $423.50
Sizes 1 kt
<B>Standard Curve</B><BR/>: Typical Standard Curve for Human PDGF R α  ELISA Kit, <B>Cat. No. RAB0399</B>. The standard curve(s) displayed are for demonstration only. A standard curve must be run with each assay.

Human Phospho-PDGF R alpha DuoSet IC ELISA - DYC2114-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00, $1,395.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-PDGF R alpha DuoSet IC, 5 Plate - DYC2114-5 from R&D Systems

Category ELISA Kit

Human Total PDGF R alpha DuoSet IC ELISA - DYC322-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)
Range 312.00 - 20,000 pg/mL

Human Total PDGF R alpha DuoSet IC, 5 Plate - DYC322-5 from R&D Systems

Category ELISA Kit

Human PDGFRa ELISA Kit - abx152681 from Abbexa

Category ELISA Kit
Sensitivity 0.060 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Alpha-type platelet-derived growth factor receptor, PDGFRA, Human, ELISA Kit - E0111h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL
Search more