PDGFRA

Gene Symbol	PDGFRA
Entrez Gene	5156
Alt Symbol	CD140A, PDGFR-2, PDGFR2, RHEPDGFRA
Species	Human
Gene Type	protein-coding
Description	platelet-derived growth factor receptor, alpha polypeptide
Other Description	CD140 antigen-like family member A|CD140a antigen|PDGF-R-alpha|PDGFRA/BCR fusion|alpha-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 2|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
Swissprots	E9PBH0 P16234 B2RE69 Q96KZ7 Q6P4H5 Q9UD28
Accessions	BAA08742 CAJ33669 CAJ33686 CAN37625 CBH30545 EAX05457 EAX05458 P16234 AA599881 AA625689 AK308353 AK311006 AK316578 BAG38166 AV689272 BC015186 AAH15186 BC063414 AAH63414 DA678599 L25829 M21574 AAA96715 M22734 AAA60048 M30494 X76079 XM_005265743 XP_005265800 XM_006714039 XP_006714102 XM_006714041 XP_006714104 XM_011534385 XP_011532687 XM_011534386 XP_011532688 NM_006206 NP_006197
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever
Subcellular Location	Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single- pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Note=The activated receptor is rapidly internalized and degraded.
Tissue Specificity	Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. {ECO:0000269|PubMed:2536956, ECO:0000269|PubMed:7896447, ECO:0000269|PubMed:8188664}.
Top Pathways	Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDGF Receptor alpha (mutated T674 I) protein fragment - ab119720 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active PDGF Receptor alpha protein fragment - ab84797 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source Insect cells

Active PDGF Receptor alpha protein fragment - ab60755 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Insect cells

Human PDGF Receptor alpha full length protein - ab132929 from Abcam Category Protein Source Wheat germ Species Human

Human PDGF Receptor alpha protein fragment - ab109932 from Abcam Category Protein Source E. coli Species Human

PDGF Receptor alpha peptide - ab107908 from Abcam Category Peptide

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E3115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E9167 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E9170 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E9166 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E9168 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGFRA / PDGFR Alpha Antibody Blocking Peptide - LS-E9169 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGF R alpha Partial Recombinant Protein - H00005156-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDGF R alpha Recombinant Protein - H00005156-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDGF R alpha Recombinant Protein - P4748 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human PDGF R alpha Protein - NBP1-72398 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

PDGF R alpha Recombinant Protein - H00005156-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

PDGF R alpha Peptide - P2709 from Novus Biologicals Category Peptide Species Human

PDGF R alpha Peptide - P2707 from Novus Biologicals Category Peptide Species Human

PDGF R alpha Peptide - P2705 from Novus Biologicals Category Peptide Species Human

PDGF R alpha Peptide - P2704 from Novus Biologicals Category Peptide Species Human

PDGFRA-Antibody-Y754-Blocking-Peptide - BP7666j from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDGFRA-Antibody-Y768-Blocking-Peptide - BP7666h from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDGFRA-Antibody-Y762-Blocking-Peptide - BP7666f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDGFRA-Antibody-Y720-Blocking-Peptide - BP7666d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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