| Gene Symbol |
CNIH2
|
| Entrez Gene |
254263
|
| Alt Symbol |
CNIH-2, Cnil
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cornichon family AMPA receptor auxiliary protein 2
|
| Other Description |
cornichon homolog 2|protein cornichon homolog 2
|
| Swissprots |
Q6PI25
|
| Accessions |
EAW74508 Q6PI25 AI928591 AY726585 BC047953 AAH47953 BC160083 AAI60083 BM547951 DR760677 HQ448517 ADQ32996 NM_182553 NP_872359 NR_073078 NR_073079
|
| Function |
Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
|
| Tissue Specificity |
Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}.
|
![Western Blot: CNIH2 Overexpression Lysate (Adult Normal) [NBP2-04844] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNIH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/23337_CNIH2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-04844-img0001.jpg)