Gene Symbol | CNIH2 |
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Entrez Gene | 254263 |
Alt Symbol | CNIH-2, Cnil |
Species | Human |
Gene Type | protein-coding |
Description | cornichon family AMPA receptor auxiliary protein 2 |
Other Description | cornichon homolog 2|protein cornichon homolog 2 |
Swissprots | Q6PI25 |
Accessions | EAW74508 Q6PI25 AI928591 AY726585 BC047953 AAH47953 BC160083 AAI60083 BM547951 DR760677 HQ448517 ADQ32996 NM_182553 NP_872359 NR_073078 NR_073079 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}. |
Tissue Specificity | Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}. |
Human Protein cornichon homolog 2 full length protein - ab166032 from Abcam
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CNIH2 Antibody Blocking Peptide - LS-E1047 from LifeSpan Bioscience
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CNIH2 Antibody Blocking Peptide - LS-E24542 from LifeSpan Bioscience
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Recombinant Human CNIH2 Protein - H00254263-P01 from Novus Biologicals
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CNIH2-Antibody-N-term-Blocking-peptide - BP11529a from Abgent, a WuXi AppTec company
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Cornichon homolog 2 - H00254263-P01-10 from Acris Antibodies
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Cornichon homolog 2 - H00254263-P01-25 from Acris Antibodies
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CNIH2 fusion protein - Ag5533 from Proteintech Group
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CNIH2 fusion protein - ag15074 from Proteintech Group
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Recombinant Human CNIH2, GST-tagged - CNIH2-11380H from Creative Biomart
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Cornichon homolog 2 - TP315357 from Acris Antibodies
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CNIH2 Peptide, Human - M34GP03364H from Creative Peptides
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Protein cornichon homolog 2 (CNIH2), Recombinant Protein - MBS7011871 from MyBioSource
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