Gene Symbol | CNIH2 |
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Entrez Gene | 254263 |
Alt Symbol | CNIH-2, Cnil |
Species | Human |
Gene Type | protein-coding |
Description | cornichon family AMPA receptor auxiliary protein 2 |
Other Description | cornichon homolog 2|protein cornichon homolog 2 |
Swissprots | Q6PI25 |
Accessions | EAW74508 Q6PI25 AI928591 AY726585 BC047953 AAH47953 BC160083 AAI60083 BM547951 DR760677 HQ448517 ADQ32996 NM_182553 NP_872359 NR_073078 NR_073079 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}. |
Tissue Specificity | Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}. |
CNIH2 CRISPR/Cas9 KO Plasmid (h) - sc-407881 from Santa Cruz Biotechnology
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CNIH2 HDR Plasmid (h) - sc-407881-HDR from Santa Cruz Biotechnology
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CNIH2 Double Nickase Plasmid (h) - sc-407881-NIC from Santa Cruz Biotechnology
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CNIH2 Double Nickase Plasmid (h2) - sc-407881-NIC-2 from Santa Cruz Biotechnology
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CNIH2 CRISPR Activation Plasmid (h) - sc-407881-ACT from Santa Cruz Biotechnology
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CNIH2 CRISPR Activation Plasmid (h2) - sc-407881-ACT-2 from Santa Cruz Biotechnology
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CNIH2 Lentiviral Activation Particles (h) - sc-407881-LAC from Santa Cruz Biotechnology
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CNIH2 Lentiviral Activation Particles (h2) - sc-407881-LAC-2 from Santa Cruz Biotechnology
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CNIH2 siRNA (h) - sc-96410 from Santa Cruz Biotechnology
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CNIH2 shRNA Plasmid (h) - sc-96410-SH from Santa Cruz Biotechnology
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CNIH2 shRNA (h) Lentiviral Particles - sc-96410-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6304 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6304 from Sigma-Aldrich
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CNIH2 siRNA (Human) - CRJ6678 from Cohesion Biosciences
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CNIH2 - MBS8206296 from MyBioSource
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shRNA set against Human CNIH2 (NM_182553.2) - SHH266237 from Creative biogene
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Human CNIH2 siRNA - orb277179 from Biorbyt
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CNIH2 shRNA Plasmid (Human) - CHJ6678 from Cohesion Biosciences
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CNIH2 miRNA 3'UTR clone - MiUTR3H-11776 from Creative biogene
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