SSTR2

Gene Symbol	SSTR2
Entrez Gene	6752
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	somatostatin receptor 2
Other Description	SRIF-1|SS2R|somatostatin receptor type 2
Swissprots	Q9BWH1 Q4VBP0 P30874 B2R9P7 A8K3Y0 Q96TF2 Q96GE0
Accessions	AAA58248 AAC98545 AAF42809 AAF42810 AAO92064 BAC06126 CBE74681 CBX87732 CBX87733 CDM63481 EAW89111 EAW89112 P30874 AK093950 AK290745 BAF83434 AK313866 BAG36594 BC000256 AAH00256 BC009522 AAH09522 BC019610 AAH19610 BC095495 AAH95495 BT019926 AAV38729 DQ891280 ABM82206 NM_001050 NP_001041
Function	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Tissue Specificity	Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. {ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22932785}.
Top Pathways	Gastric acid secretion, cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SSTR2 (A-8) - sc-365502 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SSTR2 (A-20) - sc-11606 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SSTR2 (H-50) - sc-25676 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SSTR2a (C-15) - sc-11608 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SSTR2b (C-15) - sc-11609 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Somatostatin Receptor 2 antibody - ab9550 from Abcam Prices $373.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Somatostatin Receptor 2 antibody [UMB1] - ab134152 from Abcam Prices $392.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone UMB1

Anti-SSTR2 Antibody (C-Terminus) - LS-C10288 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (C-Terminus) - LS-C75922 from LifeSpan Bioscience Prices $515.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody - LS-C75923 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SSTR2 Antibody (aa184-198) - LS-C312843 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (aa130-180) - LS-C203247 from LifeSpan Bioscience Prices $245.00, $325.00 Sizes 40 µg, 100 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody - LS-C341108 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody - LS-C341703 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (aa241-290) - LS-C135550 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody - LS-C332379 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (C-Terminus) - LS-C201741 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (C-Terminus) IHC-plus™ - LS-A1001 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (C-Terminus) IHC-plus™ - LS-B312 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A999 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SSTR2 Antibody (Extracellular Domain) IHC-plus™ - LS-A998 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Somatostatin R2/SSTR2 Antibody - NB300-157 from Novus Biologicals Prices $129.00, $349.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

Somatostatin R2/SSTR2 Antibody (402038) [Unconjugated] - MAB4224 from Novus Biologicals Prices $99.00, $259.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 402038

Somatostatin R2/SSTR2 Antibody - NB100-74537 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Somatostatin R2/SSTR2 Antibody - NLS998 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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