SSTR2

Gene Symbol	SSTR2
Entrez Gene	6752
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	somatostatin receptor 2
Other Description	SRIF-1|SS2R|somatostatin receptor type 2
Swissprots	Q9BWH1 Q4VBP0 P30874 B2R9P7 A8K3Y0 Q96TF2 Q96GE0
Accessions	AAA58248 AAC98545 AAF42809 AAF42810 AAO92064 BAC06126 CBE74681 CBX87732 CBX87733 CDM63481 EAW89111 EAW89112 P30874 AK093950 AK290745 BAF83434 AK313866 BAG36594 BC000256 AAH00256 BC009522 AAH09522 BC019610 AAH19610 BC095495 AAH95495 BT019926 AAV38729 DQ891280 ABM82206 NM_001050 NP_001041
Function	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Tissue Specificity	Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. {ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22932785}.
Top Pathways	Gastric acid secretion, cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Somatostatin receptor type 2, SSTR2, Human, ELISA Kit - E2292h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

somatostatin receptor 2, ELISA Kit - MBS2602769 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml. Range 20 ng/ml-0.312 ng/ml

Somatostatin Receptor 2 (SSTR2), ELISA Kit - MBS9312063 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SSTR2, ELISA Kit - MBS2515820 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

Bovine SSTR2 ELISA Kit (Custom ELISA) - LS-F19696 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Human SSTR2 ELISA Kit (Custom ELISA) - LS-F19695 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Pig SSTR2 ELISA Kit (Custom ELISA) - LS-F19699 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Dog SSTR2 ELISA Kit (Custom ELISA) - LS-F19698 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Mouse SSTR2 ELISA Kit (Custom ELISA) - LS-F19697 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Rat SSTR2 ELISA Kit (Custom ELISA) - LS-F19694 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 125-8000 pg/ml

Human FPB(Fibrinopeptide B) ELISA Kit - E-EL-H2197 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 75 pg/mLpg/mL Range 125~8000 pg/mL

Human Somatostatin receptor type 2 ELISA Kit - abx251546 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human SSTR2 ELISA Kit (Sandwich ELISA) - LS-F24241 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 125 pg/ml Range 125-8000 pg/ml

Human SSTR2(Somatostatin Receptor 2) ELISA Kit - E-EL-H2197 from Elabscience Category ELISA Kit Sensitivity 75.00 pg/mL Range 125.00—8000 pg/mL

Somatostatin Receptor 2, SSTR2, Human, ELISA Kit - E-EL-H2197 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 75 Range 125-8000pg/mL

Human Somatostatin receptor type 2 ELISA Kit - EKE51986 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 33 pg/mL Range 78-5000 pg/mL

SSTR2 - EKH4408 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

SSTR2 ELISA Kit (Human) : 96 Wells (OKEH01626) - OKEH01626 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 33 pg/mL Range 78 - 5000 pg/mL

Human SSTR2 ELISA Kit - E036154 from Biobool Category ELISA Kit Sensitivity 0.06 ng/ml.

Human Somatostatin receptor type 2 ELISA Kit - EK4483 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.078ng/mL Range 0.156-10 ng/mL

Somatostatin receptor type 2 (SSTR2), ELISA Kit - MBS2610279 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Somatostatin receptor type 2, ELISA Kit - MBS2603348 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Somatostatin receptor type 2, ELISA Kit - MBS2603865 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Somatostatin receptor type 2 , ELISA Kit - MBS2604233 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Somatostatin receptor type 2, ELISA Kit - MBS2603619 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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