SSTR2

Gene Symbol	SSTR2
Entrez Gene	6752
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	somatostatin receptor 2
Other Description	SRIF-1|SS2R|somatostatin receptor type 2
Swissprots	Q9BWH1 Q4VBP0 P30874 B2R9P7 A8K3Y0 Q96TF2 Q96GE0
Accessions	AAA58248 AAC98545 AAF42809 AAF42810 AAO92064 BAC06126 CBE74681 CBX87732 CBX87733 CDM63481 EAW89111 EAW89112 P30874 AK093950 AK290745 BAF83434 AK313866 BAG36594 BC000256 AAH00256 BC009522 AAH09522 BC019610 AAH19610 BC095495 AAH95495 BT019926 AAV38729 DQ891280 ABM82206 NM_001050 NP_001041
Function	Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Tissue Specificity	Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. {ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22932785}.
Top Pathways	Gastric acid secretion, cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Somatostatin Receptor 2 full length protein - ab152708 from Abcam Category Protein Source Wheat germ Species Human

Human Somatostatin Receptor 2 protein fragment - ab112356 from Abcam Category Protein Source Wheat germ Species Human

Human Somatostatin Receptor 2 protein fragment - ab114373 from Abcam Category Protein Source Wheat germ Species Human

Somatostatin Receptor 2 peptide - ab171899 from Abcam Category Peptide

SSTR2 Antibody Blocking Peptide - LS-E21794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SSTR2 Antibody Blocking Peptide - LS-E28091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SSTR2 Antibody Blocking Peptide - LS-E29828 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SSTR2 Antibody Blocking Peptide - LS-E29829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Somatostatin R2/SSTR2 Blocking Peptide - NB300-157PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Rat

Recombinant Human Somatostatin R2/SSTR2 Protein - H00006752-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Somatostatin R2/SSTR2 Protein - H00006752-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Somatostatin R2/SSTR2 Protein - H00006752-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Somatostatin R2/SSTR2 Protein - H00006752-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 2 µg Source Wheat Germ Species Human

SSTR2 peptide - orb73234 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

SSTR2 peptide - orb218880 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Drosophila, Sheep, Cat

SSTR2 Blocking Peptide - 33R-8247 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SSTR2 Blocking Peptide - abx064211 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Sheep

SSTR2 - H00006752-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

SSTR2 - H00006752-P01 from Acris Antibodies Category Protein Species Human

SSTR2 - H00006752-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SSTR2 - H00006752-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SSTR2 - H00006752-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Somatostatin Receptor 2 (SSTR2), Human - 20-9144 from ARP American Research Products Category Protein Prices $499.00 Sizes 50 µg Source E.coli Species Human

SSTR2 fusion protein - Ag14205 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SSTR2 fusion protein - ag14554 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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