| Gene Symbol | ATP5H |
|---|---|
| Entrez Gene | 10476 |
| Alt Symbol | ATPQ |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d |
| Other Description | ATP synthase D chain, mitochondrial|ATP synthase subunit d, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d|ATP synthase, H+ transporting, mitochondrial F1F0, subunit d|ATPase subunit d|My032 protein |
| Swissprots | Q9H3J4 O75947 B2R5L6 |
| Accessions | EAW89228 EAW89229 O75947 AA608885 AF061735 AAG43146 AF070650 AAD20956 AF086159 AF087135 AAC36338 AK095671 AK312230 BAG35163 BC029392 AAH29392 BC032245 AAH32245 BC038092 AAH38092 DQ583597 NM_001003785 NP_001003785 NM_006356 NP_006347 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |