ATP5H
| Gene Symbol | ATP5H |
|---|---|
| Entrez Gene | 10476 |
| Alt Symbol | ATPQ |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d |
| Other Description | ATP synthase D chain, mitochondrial|ATP synthase subunit d, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d|ATP synthase, H+ transporting, mitochondrial F1F0, subunit d|ATPase subunit d|My032 protein |
| Swissprots | Q9H3J4 O75947 B2R5L6 |
| Accessions | EAW89228 EAW89229 O75947 AA608885 AF061735 AAG43146 AF070650 AAD20956 AF086159 AF087135 AAC36338 AK095671 AK312230 BAG35163 BC029392 AAH29392 BC032245 AAH32245 BC038092 AAH38092 DQ583597 NM_001003785 NP_001003785 NM_006356 NP_006347 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
ATP5H CRISPR/Cas9 KO Plasmid (h) - sc-403948 from Santa Cruz Biotechnology
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ATP5H HDR Plasmid (h) - sc-403948-HDR from Santa Cruz Biotechnology
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ATP5H Double Nickase Plasmid (h) - sc-403948-NIC from Santa Cruz Biotechnology
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ATP5H Double Nickase Plasmid (h2) - sc-403948-NIC-2 from Santa Cruz Biotechnology
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ATP5H CRISPR Activation Plasmid (h) - sc-403948-ACT from Santa Cruz Biotechnology
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ATP5H CRISPR Activation Plasmid (h2) - sc-403948-ACT-2 from Santa Cruz Biotechnology
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ATP5H Lentiviral Activation Particles (h) - sc-403948-LAC from Santa Cruz Biotechnology
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ATP5H Lentiviral Activation Particles (h2) - sc-403948-LAC-2 from Santa Cruz Biotechnology
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ATP5H siRNA (h) - sc-93691 from Santa Cruz Biotechnology
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ATP5H shRNA Plasmid (h) - sc-93691-SH from Santa Cruz Biotechnology
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ATP5H shRNA (h) Lentiviral Particles - sc-93691-V from Santa Cruz Biotechnology
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ATP5H RNAi - H00010476-R01 from Novus Biologicals
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MISSION® esiRNA - EHU128441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3704 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3704 from Sigma-Aldrich
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ATP5H siRNA (Human) - CRH7113 from Cohesion Biosciences
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ATP5H RNAi - H00010476-R02 from Novus Biologicals
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ATP5H - MBS8223736 from MyBioSource
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shRNA set against Human ATP5H(NM_006356.2) - SHG082577 from Creative biogene
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shRNA set against Human ATP5H(NM_001003785.1) - SHG082725 from Creative biogene
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shRNA set against Human ATP5H(NM_006356.2) - SHG082779 from Creative biogene
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Human ATP5H siRNA - orb267615 from Biorbyt
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ATP5H shRNA Plasmid (Human) - CHH7113 from Cohesion Biosciences
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ATP5H miRNA 3'UTR clone - MiUTR1H-00699 from Creative biogene
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ATP5H miRNA 3'UTR clone - MiUTR1H-00700 from Creative biogene
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