| Gene Symbol |
NR2C2
|
| Entrez Gene |
7182
|
| Alt Symbol |
TAK1, TR4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 2, group C, member 2
|
| Other Description |
Nuclear hormone receptor TR4|nuclear receptor subfamily 2 group C member 2|orphan nuclear receptor TAK1|orphan nuclear receptor TR4|testicular nuclear receptor 4
|
| Swissprots |
A8K3H5 P55092 P49116 B6ZGT8
|
| Accessions |
AAC50672 AAC50673 AAC50675 AAC50676 EAW64213 EAW64214 EAW64215 P49116 AB307708 BAH02299 AI986459 AK091226 AK094590 AK290590 BAF83279 BC030715 BC051670 AAH51670 BF307171 CA430806 HQ995528 ADZ31973 L27586 AAA21474 XM_011534058 XP_011532360 XM_011534059 XP_011532361 XM_011534060 XP_011532362 XM_011534061 XP_011532363 XM_011534062 XP_011532364 XM_011534063 XP_011532365 XM_011534064 XP_011532366 XM_011534065 XP_011532367 XM_011534066 XP_011532368 NM_001291694 NP_001278623 NM_003298 NP_003289
|
| Function |
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:00
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:10644740}.
|