NR2C2

Gene Symbol	NR2C2
Entrez Gene	7182
Alt Symbol	TAK1, TR4
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 2, group C, member 2
Other Description	Nuclear hormone receptor TR4|nuclear receptor subfamily 2 group C member 2|orphan nuclear receptor TAK1|orphan nuclear receptor TR4|testicular nuclear receptor 4
Swissprots	A8K3H5 P55092 P49116 B6ZGT8
Accessions	AAC50672 AAC50673 AAC50675 AAC50676 EAW64213 EAW64214 EAW64215 P49116 AB307708 BAH02299 AI986459 AK091226 AK094590 AK290590 BAF83279 BC030715 BC051670 AAH51670 BF307171 CA430806 HQ995528 ADZ31973 L27586 AAA21474 XM_011534058 XP_011532360 XM_011534059 XP_011532361 XM_011534060 XP_011532362 XM_011534061 XP_011532363 XM_011534062 XP_011532364 XM_011534063 XP_011532365 XM_011534064 XP_011532366 XM_011534065 XP_011532367 XM_011534066 XP_011532368 NM_001291694 NP_001278623 NM_003298 NP_003289
Function	Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:00
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:10644740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TR4 CRISPR/Cas9 KO Plasmid (h) - sc-407244 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 HDR Plasmid (h) - sc-407244-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 Double Nickase Plasmid (h) - sc-407244-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 Double Nickase Plasmid (h2) - sc-407244-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 CRISPR Activation Plasmid (h) - sc-407244-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 CRISPR Activation Plasmid (h2) - sc-407244-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 Lentiviral Activation Particles (h) - sc-407244-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 Lentiviral Activation Particles (h2) - sc-407244-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TR4 siRNA (h) - sc-38894 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TR4 shRNA Plasmid (h) - sc-38894-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TR4 shRNA (h) Lentiviral Particles - sc-38894-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TR4/NR2C2 RNAi - H00007182-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TR4/NR2C2 RNAi - H00007182-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU042021 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15491 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15491 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

NR2C2 siRNA (Human) - CRH4932 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NR2C2 (NM_003298.3) - SHH354736 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NR2C2(NM_003298.3) - SHR020382 from Creative biogene Category siRNA Species Reactivities Human

Human NR2C2 siRNA - orb265434 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NR2C2 shRNA Plasmid (Human) - CHH4932 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NR2C2 miRNA 3'UTR clone - MiUTR1H-06901 from Creative biogene Species Reactivities Human

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