| Gene Symbol |
CDK9
|
| Entrez Gene |
1025
|
| Alt Symbol |
C-2k, CDC2L4, CTK1, PITALRE, TAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 9
|
| Other Description |
CDC2-related kinase|cell division cycle 2-like protein kinase 4|cell division protein kinase 9|serine/threonine protein kinase PITALRE|tat-associated kinase complex catalytic subunit
|
| Swissprots |
Q96TF1 P50750 Q5JU24 Q5U006 Q5JU25
|
| Accessions |
AAF72183 AAM54039 EAW87696 EAW87697 P50750 AB451289 BAG70103 AB451421 BAG70235 AK313828 BAG36563 BC001968 AAH01968 BE549667 BT019903 AAV38706 BX091973 DB120461 DQ891182 ABM82108 DQ894364 ABM85290 DQ894365 ABM85291 L25676 AAA35668 X80230 CAA56516 NM_001261 NP_001252
|
| Function |
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio
|
| Subcellular Location |
Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Transcriptional misregulation in cancer
|
