CDK9

Gene Symbol	CDK9
Entrez Gene	1025
Alt Symbol	C-2k, CDC2L4, CTK1, PITALRE, TAK
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 9
Other Description	CDC2-related kinase|cell division cycle 2-like protein kinase 4|cell division protein kinase 9|serine/threonine protein kinase PITALRE|tat-associated kinase complex catalytic subunit
Swissprots	Q96TF1 P50750 Q5JU24 Q5U006 Q5JU25
Accessions	AAF72183 AAM54039 EAW87696 EAW87697 P50750 AB451289 BAG70103 AB451421 BAG70235 AK313828 BAG36563 BC001968 AAH01968 BE549667 BT019903 AAV38706 BX091973 DB120461 DQ891182 ABM82108 DQ894364 ABM85290 DQ894365 ABM85291 L25676 AAA35668 X80230 CAA56516 NM_001261 NP_001252
Function	Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio
Subcellular Location	Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
Tissue Specificity	Ubiquitous.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cdk9 full length protein - ab85603 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk9 full length protein - ab158090 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Cdk9 peptide - ab39096 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk9 peptide - ab39097 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk9 protein fragment - ab158091 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDK9 Antibody Blocking Peptide - LS-E3957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK9 Antibody Blocking Peptide - LS-E10501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cdk9 Partial Recombinant Protein - H00001025-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cdk9 Protein - H00001025-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

CDK9-Antibody-C-term-Blocking-peptide - BP13892b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK9 Protein Lysate (APL10661) - APL10661 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CDK9 Blocking Peptide - 33R-7070 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CDK9 Blocking Peptide - abx064138 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig

CDK9 - H00001025-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CDK9 - H00001025-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

CDK9 - H00001025-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

CDK9 - H00001025-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDK9 - H00001025-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDK9 - P4664 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

CDK9 - P5518 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

CDK9 fusion protein - ag2318 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active - CDK9-280H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus .

Recombinant Human CDK9 - CDK9-26809TH from Creative Biomart Category Protein

Recombinant Human CDK9 - CDK9-27909TH from Creative Biomart Category Protein

Recombinant Cyclin Dependent Kinase 9 (CDK9) - RPA496Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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