Gene Symbol | MAGEA1 |
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Entrez Gene | 4100 |
Alt Symbol | CT1.1, MAGE1 |
Species | Human |
Gene Type | protein-coding |
Description | melanoma antigen family A1 |
Other Description | MAGE-1 antigen|antigen MZ2-E|cancer/testis antigen 1.1|cancer/testis antigen family 1, member 1|melanoma antigen MAGE-1|melanoma antigen family A 1|melanoma antigen family A, 1 (directs expression of antigen MZ2-E)|melanoma-associated antigen 1|melanoma-associated antigen MZ2-E |
Swissprots | B2RC81 P43355 O00346 |
Accessions | AAA03229 AAB33086 CAT04602 EAW72885 P43355 AF463515 AAL69948 AK314979 BAG37478 AY148486 AAN62752 BC017555 AAH17555 BP314195 BT009789 AAP88791 CA428506 DB053667 DQ891149 ABM82075 DQ894329 ABM85255 EU161102 ABW06861 NM_004988 NP_004979 |
Function | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
MAGE (6A111) - sc-71537 from Santa Cruz Biotechnology
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MAGE (5G152) - sc-71536 from Santa Cruz Biotechnology
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MAGE (A-16) - sc-31321 from Santa Cruz Biotechnology
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MAGE (FL-309) - sc-10749 from Santa Cruz Biotechnology
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MAGE (I-17) - sc-31320 from Santa Cruz Biotechnology
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MAGE (Y-18) - sc-12805 from Santa Cruz Biotechnology
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MAGE-A1 (MA454) - sc-20033 from Santa Cruz Biotechnology
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MAGE-A (6C1) - sc-20034 from Santa Cruz Biotechnology
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MAGE-A1 (3F256) - sc-71539 from Santa Cruz Biotechnology
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Anti-MAGE 1 antibody - ab21472 from Abcam
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Anti-MAGE 1 antibody - ab38486 from Abcam
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Anti-MAGE 1 antibody - ab53131 from Abcam
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Anti-MAGE 1 antibody - ab80699 from Abcam
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Anti-MAGE 1 antibody - ab16031 from Abcam
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Anti-MAGE 1 antibody [EPR4276] - ab109108 from Abcam
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Anti-MAGE 1 antibody [MA454] - ab193330 from Abcam
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Anti-MAGE 1 antibody [MA454] (Biotin) - ab79475 from Abcam
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Anti-MAGE 1 antibody, prediluted - ab16034 from Abcam
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Anti-MAGE 1 antibody [SP194] - C-terminal - ab183309 from Abcam
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Anti-MAGE 1 antibody [SPM282] - ab25834 from Abcam
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Anti-MAGE 1 antibody [SPM282], prediluted - ab54302 from Abcam
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Anti-MAGEA1 / MAGE 1 Antibody (aa245-259) IHC-plus⢠- LS-B1219 from LifeSpan Bioscience
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Anti-MAGEA1 / MAGE 1 Antibody - LS-C346090 from LifeSpan Bioscience
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Anti-MAGEA1 / MAGE 1 Antibody (aa158-174) IHC-plus⢠- LS-B881 from LifeSpan Bioscience
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Anti-MAGEA1 / MAGE 1 Antibody (C-Terminus, clone SP188) - LS-C210415 from LifeSpan Bioscience
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