Gene Symbol | MAGEA1 |
---|---|
Entrez Gene | 4100 |
Alt Symbol | CT1.1, MAGE1 |
Species | Human |
Gene Type | protein-coding |
Description | melanoma antigen family A1 |
Other Description | MAGE-1 antigen|antigen MZ2-E|cancer/testis antigen 1.1|cancer/testis antigen family 1, member 1|melanoma antigen MAGE-1|melanoma antigen family A 1|melanoma antigen family A, 1 (directs expression of antigen MZ2-E)|melanoma-associated antigen 1|melanoma-associated antigen MZ2-E |
Swissprots | B2RC81 P43355 O00346 |
Accessions | AAA03229 AAB33086 CAT04602 EAW72885 P43355 AF463515 AAL69948 AK314979 BAG37478 AY148486 AAN62752 BC017555 AAH17555 BP314195 BT009789 AAP88791 CA428506 DB053667 DQ891149 ABM82075 DQ894329 ABM85255 EU161102 ABW06861 NM_004988 NP_004979 |
Function | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}. |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
Active human MAGE 1 full length protein - ab75539 from Abcam
|
||||||||||
MAGEA1 / MAGE 1 Antibody Blocking Peptide - LS-E8103 from LifeSpan Bioscience
|
||||||||||
MAGEA1 / MAGE 1 Antibody Blocking Peptide - LS-E16813 from LifeSpan Bioscience
|
||||||||||
MAGEA1 / MAGE 1 Antibody Blocking Peptide - LS-E16814 from LifeSpan Bioscience
|
||||||||||
Recombinant Human MAGE 1 Protein - H00004100-P01 from Novus Biologicals
|
||||||||||
Recombinant Human MAGE 1 Protein - H00004100-Q01 from Novus Biologicals
|
||||||||||
Recombinant Human MAGE 1 Protein - NBP1-99669 from Novus Biologicals
|
||||||||||
MAGE 1 Peptide - P1771 from Novus Biologicals
|
||||||||||
MAGEA1-Antibody-Center-Blocking-Peptide - BP6163a from Abgent, a WuXi AppTec company
|
||||||||||
Mage-1-Antigen-161-169-human - SP2633b from Abgent, a WuXi AppTec company
|
||||||||||
Mage-1-Antigen-161-169-human - SP2633a from Abgent, a WuXi AppTec company
|
||||||||||
MAGE 1 recombinant protein - GTX65168 from GeneTex
|
||||||||||
MAGEA1 Protein Lysate (APL10498) - APL10498 from Aviva Systems Biology
|
||||||||||
MAGEA1 Protein Lysate (APL10500) - APL10500 from Aviva Systems Biology
|
||||||||||
MAGEA1 Protein (OPPA01227) - OPPA01227 from Aviva Systems Biology
|
||||||||||
Human Melanoma Antigen Family A, 1 protein - orb81205 from Biorbyt
|
||||||||||
MAGE-1 Antigen peptide - orb72943 from Biorbyt
|
||||||||||
MAGE1 protein - 30R-2720 from Fitzgerald
|
||||||||||
MAGEA1 Blocking Peptide - 33R-5524 from Fitzgerald
|
||||||||||
MAGEA1 Blocking Peptide - 33R-6107 from Fitzgerald
|
||||||||||
MAGEA1 Blocking Peptide - abx062908 from Abbexa
|
||||||||||
MAGE-1 - H00004100-P01-02 from Acris Antibodies
|
||||||||||
MAGE-1 - H00004100-P02-10 from Acris Antibodies
|
||||||||||
MAGE-1 - H00004100-P02-25 from Acris Antibodies
|
||||||||||
MAGE-1 - H00004100-Q01-10 from Acris Antibodies
|