MAGEA1
| Gene Symbol | MAGEA1 |
|---|---|
| Entrez Gene | 4100 |
| Alt Symbol | CT1.1, MAGE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | melanoma antigen family A1 |
| Other Description | MAGE-1 antigen|antigen MZ2-E|cancer/testis antigen 1.1|cancer/testis antigen family 1, member 1|melanoma antigen MAGE-1|melanoma antigen family A 1|melanoma antigen family A, 1 (directs expression of antigen MZ2-E)|melanoma-associated antigen 1|melanoma-associated antigen MZ2-E |
| Swissprots | B2RC81 P43355 O00346 |
| Accessions | AAA03229 AAB33086 CAT04602 EAW72885 P43355 AF463515 AAL69948 AK314979 BAG37478 AY148486 AAN62752 BC017555 AAH17555 BP314195 BT009789 AAP88791 CA428506 DB053667 DQ891149 ABM82075 DQ894329 ABM85255 EU161102 ABW06861 NM_004988 NP_004979 |
| Function | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
MAGE-A1 CRISPR/Cas9 KO Plasmid (h) - sc-401056 from Santa Cruz Biotechnology
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MAGE-A1 HDR Plasmid (h) - sc-401056-HDR from Santa Cruz Biotechnology
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MAGE-A1 Double Nickase Plasmid (h) - sc-401056-NIC from Santa Cruz Biotechnology
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MAGE-A1 Double Nickase Plasmid (h2) - sc-401056-NIC-2 from Santa Cruz Biotechnology
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MAGE-A1 CRISPR Activation Plasmid (h) - sc-401056-ACT from Santa Cruz Biotechnology
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MAGE-A1 CRISPR Activation Plasmid (h2) - sc-401056-ACT-2 from Santa Cruz Biotechnology
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MAGE-A1 Lentiviral Activation Particles (h) - sc-401056-LAC from Santa Cruz Biotechnology
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MAGE-A1 Lentiviral Activation Particles (h2) - sc-401056-LAC-2 from Santa Cruz Biotechnology
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MAGE-A siRNA (h) - sc-35843 from Santa Cruz Biotechnology
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MAGE-A shRNA Plasmid (h) - sc-35843-SH from Santa Cruz Biotechnology
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MAGE-A shRNA (h) Lentiviral Particles - sc-35843-V from Santa Cruz Biotechnology
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MAGE-A1 siRNA (h) - sc-37313 from Santa Cruz Biotechnology
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MAGE-A1 shRNA Plasmid (h) - sc-37313-SH from Santa Cruz Biotechnology
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MAGE-A1 shRNA (h) Lentiviral Particles - sc-37313-V from Santa Cruz Biotechnology
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MAGE 1 RNAi - H00004100-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN12909 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12909 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05154 from Sigma-Aldrich
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MAGEA1 siRNA (Human) - CRH2780 from Cohesion Biosciences
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MAGE-A1 CRISPR/Cas9 KO Plasmid (h2) - sc-401056-KO-2 from Santa Cruz Biotechnology
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MAGE-A1 HDR Plasmid (h2) - sc-401056-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MAGEA1 (NM_004988.4) - SHH336703 from Creative biogene
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shRNA set against Human MAGEA1(NM_004988.4) - SHH170561 from Creative biogene
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MAGEA1 shRNA Plasmid (Human) - CHH2780 from Cohesion Biosciences
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MAGEA1 miRNA 3'UTR clone - MiUTR1H-06003 from Creative biogene
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