| Gene Symbol |
RHOB
|
| Entrez Gene |
388
|
| Alt Symbol |
ARH6, ARHB, MST081, MSTP081, RHOH6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras homolog family member B
|
| Other Description |
Aplysia RAS-related homolog 6|h6|oncogene RHO H6|ras homolog gene family, member B|rho cDNA clone 6|rho-related GTP-binding protein RhoB
|
| Swissprots |
Q9CUV7 Q5U0H6 P01121 B2R692 Q7RTR9 P62745 Q7RTN5
|
| Accessions |
AAY24345 DAA01912 EAX00819 EAX00820 P62745 AF171089 AAQ13605 AF498971 AAM21118 AK124398 BAG54035 AK309991 AK310813 AK312487 BAG35389 BC062781 BC066954 AAH66954 BK001232 DAA01138 BM669284 BT019546 AAV38353 BT019547 AAV38354 CA443347 CR542272 CAG47068 EU832788 ACE87799 GQ129351 ACT64485 M12174 AAA36565 X06820 CAA29968 NM_004040 NP_004031
|
| Function |
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269|PubMed:10508588, ECO:0000269|PubMed:15226397, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:9478917}.
|
| Subcellular Location |
Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
|