RHOB

Gene Symbol	RHOB
Entrez Gene	388
Alt Symbol	ARH6, ARHB, MST081, MSTP081, RHOH6
Species	Human
Gene Type	protein-coding
Description	ras homolog family member B
Other Description	Aplysia RAS-related homolog 6|h6|oncogene RHO H6|ras homolog gene family, member B|rho cDNA clone 6|rho-related GTP-binding protein RhoB
Swissprots	Q9CUV7 Q5U0H6 P01121 B2R692 Q7RTR9 P62745 Q7RTN5
Accessions	AAY24345 DAA01912 EAX00819 EAX00820 P62745 AF171089 AAQ13605 AF498971 AAM21118 AK124398 BAG54035 AK309991 AK310813 AK312487 BAG35389 BC062781 BC066954 AAH66954 BK001232 DAA01138 BM669284 BT019546 AAV38353 BT019547 AAV38354 CA443347 CR542272 CAG47068 EU832788 ACE87799 GQ129351 ACT64485 M12174 AAA36565 X06820 CAA29968 NM_004040 NP_004031
Function	Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. {ECO:0000269|PubMed:10508588, ECO:0000269|PubMed:15226397, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:21373644, ECO:0000269|PubMed:9478917}.
Subcellular Location	Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RHOB full length protein - ab107139 from Abcam Category Protein Source E. coli Species Human

Human RHOB full length protein - ab90744 from Abcam Category Protein Source E. coli Species Human

RHOB Antibody Blocking Peptide - LS-E1531 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RHOB Antibody Blocking Peptide - LS-E19715 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RhoB Protein - H00000388-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

RhoB Partial Recombinant Protein - H00000388-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RhoB Protein - NBP1-72304 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

ARHB-Antibody-Center-Blocking-peptide - BP12264c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RHOB Protein - GTX108600-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

RHOB Protein (OPPA00123) - OPPA00123 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia coli

Human RHOB protein - orb169193 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

RHOB Blocking Peptide - 33R-1769 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RhoB protein (His tag) - 80R-1813 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

RhoB (1-193, His-tag) - AR09996PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RhoB (1-193, His-tag) - AR09996PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RhoB - H00000388-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RhoB - H00000388-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RhoB - H00000388-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RhoB - H00000388-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RhoB, 1-193aa, Human, His tag, E.coli - 01-1889-B from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RHOB fusion protein - Ag5593 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RHOB fusion protein - Ag5916 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RHOB Human - PRPS-231 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Ras Homolog Gene Family Member B Protein - BP002360-PRO-224 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RhoB, 1-193aa, Recombinant Protein - GWB-P0982G from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

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