MAPK8IP1

Gene Symbol	MAPK8IP1
Entrez Gene	9479
Alt Symbol	IB1, JIP-1, JIP1, PRKM8IP
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 8 interacting protein 1
Other Description	C-Jun-amino-terminal kinase-interacting protein 1|IB-1|JNK MAP kinase scaffold protein 1|JNK-interacting protein 1|PRKM8 interacting protein|islet-brain 1
Swissprots	D3DQP4 O43407 Q9UQF2
Accessions	EAW68027 EAW68028 Q9UQF2 AB209720 BAD92957 AF007134 AAC19150 AF074091 AAD20443 AK293637 BAH11553 AK295942 BAG58726 BC035920 BC068470 AAH68470 BI548334 DB473314 XM_005253226 XP_005253283 NM_005456 NP_005447
Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

JIP-1 (B-7) - sc-25267 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

JIP-1 (E-19) - sc-7147 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JIP-1 (M-300) - sc-15353 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

JIP-1 (V-17) - sc-7146 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JIP-1 (2J8) - sc-53552 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-JIP1 antibody - ab24449 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JIP1 antibody - ab78948 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JIP1 antibody - ab152128 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JIP1/JIP2 Antibody (SH3 Domain) - LS-C16106 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (Ala99) - LS-C193237 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (N-Terminus) - LS-C16105 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, APC) - LS-C244809 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, Biotin) - LS-C244808 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, AP) - LS-C244807 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, FITC) - LS-C244810 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, Azide-free, HRP) - LS-C247658 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus, PE) - LS-C244811 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody - LS-C48606 from LifeSpan Bioscience Prices $410.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (phospho-Thr103) - LS-C291592 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (C-Terminus) - LS-C330491 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (phospho-Thr103) - LS-C199157 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (aa69-118) - LS-C199156 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-MAPK8IP1 / JIP1 Antibody (aa477-506) - LS-C165360 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

JIP1 Antibody - AF4366 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

MAPK8IP1 Polyclonal Antibody - bs-6255R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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