MAPK8IP1

Gene Symbol	MAPK8IP1
Entrez Gene	9479
Alt Symbol	IB1, JIP-1, JIP1, PRKM8IP
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 8 interacting protein 1
Other Description	C-Jun-amino-terminal kinase-interacting protein 1|IB-1|JNK MAP kinase scaffold protein 1|JNK-interacting protein 1|PRKM8 interacting protein|islet-brain 1
Swissprots	D3DQP4 O43407 Q9UQF2
Accessions	EAW68027 EAW68028 Q9UQF2 AB209720 BAD92957 AF007134 AAC19150 AF074091 AAD20443 AK293637 BAH11553 AK295942 BAG58726 BC035920 BC068470 AAH68470 BI548334 DB473314 XM_005253226 XP_005253283 NM_005456 NP_005447
Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

JIP1 peptide - ab52324 from Abcam Category Peptide

MAPK8IP1 / JIP1 Antibody Blocking Peptide - LS-E9901 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JIP1-Antibody-C-term-Blocking-Peptide - BP9014b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JIP 1 Blocking Peptide - 33R-10537 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

JIP1 Blocking Peptide - 33R-10862 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

MAPK8IP1 / JIP1 Control Peptide - AP00311CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

JIP1 fusion protein - Ag7404 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

JIP1 fusion protein - Ag6150 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human JIP1, His-tagged - JIP1-203H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MAPK8IP1 - MAPK8IP1-711H from Creative Biomart Category Protein Source Mammalian Cells Species Human

JIP-1 (A99) Peptide - BS9237P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human C-Jun-amino-terminal kinase-interacting protein 1(MAPK8IP1) - CSB-YP892370HU CSB-EP892370HU CSB-BP892370HU CSB-MP892370HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

JIP-1 Blocking Peptide - 3664BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

JIP-1 (153-163) - 1565 from R&D Systems Category Peptide Prices $209.00 Sizes 1 mg

MAPK8IP1 / JIP1 - TP309734 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1), Recombinant Protein - MBS1388445 from MyBioSource Category Protein Prices $1,520.00, $1,520.00, $1,745.00, $1,745.00, $2,600.00, $2,600.00, $3,045.00, $3,045.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MAPK8IP1 Peptide, Human - M34GP09206H from Creative Peptides Category Peptide Source Synthetic. Species Human

JIP1 Recombinant Protein Antigen - NBP2-58545PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JIP1 Recombinant Protein Antigen - NBP2-56324PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

JIP-1 (153-163) - R0970 from Creative Peptides Category Peptide

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