| Gene Symbol |
MAPK8IP1
|
| Entrez Gene |
9479
|
| Alt Symbol |
IB1, JIP-1, JIP1, PRKM8IP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 8 interacting protein 1
|
| Other Description |
C-Jun-amino-terminal kinase-interacting protein 1|IB-1|JNK MAP kinase scaffold protein 1|JNK-interacting protein 1|PRKM8 interacting protein|islet-brain 1
|
| Swissprots |
D3DQP4 O43407 Q9UQF2
|
| Accessions |
EAW68027 EAW68028 Q9UQF2 AB209720 BAD92957 AF007134 AAC19150 AF074091 AAD20443 AK293637 BAH11553 AK295942 BAG58726 BC035920 BC068470 AAH68470 BI548334 DB473314 XM_005253226 XP_005253283 NM_005456 NP_005447
|
| Function |
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.
|
| Top Pathways |
MAPK signaling pathway
|