Gene Symbol | CTSE |
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Entrez Gene | 1510 |
Alt Symbol | CATE |
Species | Human |
Gene Type | protein-coding |
Description | cathepsin E |
Other Description | erythrocyte membrane aspartic proteinase|slow-moving proteinase |
Swissprots | Q9UCE4 Q9NY58 Q5TZ01 P14091 Q5TZ02 Q9UCE3 |
Accessions | AAA52300 EAW91592 EAW91593 P14091 AJ250716 CAB82849 AJ250717 CAB82850 AK292057 BAF84746 AK298069 BAG60360 AU100136 BC042537 AAH42537 J05036 AAA52130 JF432419 ADZ15636 XM_011509244 XP_011507546 XM_011509245 XP_011507547 NM_001910 NP_001901 NM_148964 NP_683865 |
Function | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}. |
Subcellular Location | Endosome {ECO:0000269|PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. |
Tissue Specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes. {ECO:0000269|PubMed:11322887, ECO:0000269|PubMed:1370478, ECO:0000269|PubMed:8765029}. |
Top Pathways | Lysosome |
cathepsin E (D-8) - sc-166500 from Santa Cruz Biotechnology
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cathepsin E (C-7) - sc-166501 from Santa Cruz Biotechnology
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cathepsin E (E-8) - sc-166343 from Santa Cruz Biotechnology
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cathepsin E (E-12) - sc-166285 from Santa Cruz Biotechnology
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cathepsin E (H-40) - sc-30055 from Santa Cruz Biotechnology
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cathepsin E (C-20) - sc-6508 from Santa Cruz Biotechnology
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cathepsin E (C-11) - sc-166286 from Santa Cruz Biotechnology
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cathepsin E (N-19) - sc-6509 from Santa Cruz Biotechnology
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cathepsin E (S-19) - sc-6510 from Santa Cruz Biotechnology
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Anti-Cathepsin E antibody - ab89414 from Abcam
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Anti-Cathepsin E antibody - ab49798 from Abcam
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Anti-Cathepsin E antibody - ab49799 from Abcam
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Anti-Cathepsin E antibody - ab49800 from Abcam
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Anti-Cathepsin E antibody - ab36996 from Abcam
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Anti-Cathepsin E antibody [MM0128-4F50] - ab89309 from Abcam
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Anti-CTSE / Cathepsin E Antibody (Internal) - LS-C99298 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (C-Terminus) IHC-plus™ - LS-B523 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (C-Terminus) - LS-C77985 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (aa18-397) - LS-C127276 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (aa243-292) - LS-C291680 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (aa183-232) - LS-C145452 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (aa31-80) - LS-C146109 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (Ile292) - LS-C177512 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody (clone 2D5) - LS-C197003 from LifeSpan Bioscience
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Anti-CTSE / Cathepsin E Antibody - LS-C332217 from LifeSpan Bioscience
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