| Gene Symbol |
CTSE
|
| Entrez Gene |
1510
|
| Alt Symbol |
CATE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cathepsin E
|
| Other Description |
erythrocyte membrane aspartic proteinase|slow-moving proteinase
|
| Swissprots |
Q9UCE4 Q9NY58 Q5TZ01 P14091 Q5TZ02 Q9UCE3
|
| Accessions |
AAA52300 EAW91592 EAW91593 P14091 AJ250716 CAB82849 AJ250717 CAB82850 AK292057 BAF84746 AK298069 BAG60360 AU100136 BC042537 AAH42537 J05036 AAA52130 JF432419 ADZ15636 XM_011509244 XP_011507546 XM_011509245 XP_011507547 NM_001910 NP_001901 NM_148964 NP_683865
|
| Function |
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}.
|
| Subcellular Location |
Endosome {ECO:0000269|PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
|
| Tissue Specificity |
Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes. {ECO:0000269|PubMed:11322887, ECO:0000269|PubMed:1370478, ECO:0000269|PubMed:8765029}.
|
| Top Pathways |
Lysosome
|
