B3GNT5

Gene Symbol B3GNT5
Entrez Gene 84002
Alt Symbol B3GN-T5, beta3Gn-T5
Species Human
Gene Type protein-coding
Description UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Other Description BGnT-5|UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5|beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase|beta-1,3-Gn-T5|beta-1,3-N-acetylglucosaminyltransferase 5|beta-1,3-N-acetylglucosaminyltransferase bGnT-5|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase|lactotriaosylceramide synthase|lc(3)Cer synthase|lc3 synthase
Swissprots Q59FE3 Q8WWP9 D3DNS5 Q7L9Z5 Q9BYG0
Accessions CAC43634 CAD32047 CAD32048 EAW78333 EAW78334 EAW78335 EAW78336 Q9BYG0 AB045278 BAB40940 AB209517 BAD92754 AF368169 AAK53403 AJ304505 CAC83093 AK074235 AK074424 AK091474 BAG52370 BC028058 AAH28058 BF001695 BP270576 BU684277 DQ891070 ABM81996 DQ894252 ABM85178 XM_005247823 XP_005247880 XM_005247824 XP_005247881 XM_005247825 XP_005247882 XM_011513225 XP_011511527 XM_011513226 XP_011511528 XM_011513227 XP_011511529 XM_011513228 XP_011511530 XM_011513229 XP_011511531 NM_032047 NP_114436
Function Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus. {ECO:0000269|PubMed:11283017}.
Top Pathways Glycosphingolipid biosynthesis - lacto and neolacto series

Anti-B3GNT5 antibody - ab102998 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-B3GNT5 antibody (ab102998) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

Anti-B3GNT5 antibody - ab69272 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-B3GNT5 antibody (ab69272) at 1/500 dilutionLane 1 : B3GNT5 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-B3GNT5 Antibody (aa118-145, APC) - LS-C221506 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145, AP) - LS-C221507 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145, Biotin) - LS-C221509 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145, FITC) - LS-C221510 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145, Azide-free, HRP) - LS-C221511 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145, PE) - LS-C221512 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody - LS-C306475 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa124-154) - LS-C319740 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-B3GNT5 Antibody (aa118-145) - LS-C156712 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of B3GNT5 Antibody in mouse liver tissue lysates (35 ug/lane). B3GNT5 (arrow) was detected using the purified antibody.

Anti-B3GNT5 Antibody - LS-C332623 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse lung cell line, using B3GNT5 antibody.

B3GNT5 Antibody - NBP1-88954 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: B3GNT5 Antibody [NBP1-88954] - Staining of human liver shows moderate granular positivity in hepatocytes.

B3GNT5 Antibody - H00084002-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: B3GNT5 Antibody [H00084002-B01P] - Analysis of B3GNT5 expression in transfected 293T cell line by B3GNT5 polyclonal antibody. Lane 1: B3GNT5 transfected lysate(41.58 KDa). Lane 2: Non-transfected lysate.

Anti-B3GNT5 antibody produced in mouse - SAB1408083 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-B3GNT5: <B>Cat. No. SAB1408083</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~41.6 kDa using B3GNT5 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-B3GNT5 antibody produced in rabbit - HPA017292 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-B3GNT5: <B>Cat. No. HPA017292</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows moderate granular positivity in hepatocytes.

B3GNT5-Antibody-Center - AP9649c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
B3GNT5 Antibody (Center) (Cat. #AP9649c) western blot analysis in 293,MDA-MB435,HL-60 cell line lysates (35ug/lane).This demonstrates the B3GNT5 antibody detected the B3GNT5 protein (arrow).

B3GNT5 Antibody - middle region (OAAB06245) - OAAB06245 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Anti -B3GNT5 (B3GN-T5, beta3Gn-T5, beta-1,3-N-acetylglucosaminyltransferase) - 209700 from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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