B3GNT5

Gene Symbol B3GNT5
Entrez Gene 84002
Alt Symbol B3GN-T5, beta3Gn-T5
Species Human
Gene Type protein-coding
Description UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Other Description BGnT-5|UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5|beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase|beta-1,3-Gn-T5|beta-1,3-N-acetylglucosaminyltransferase 5|beta-1,3-N-acetylglucosaminyltransferase bGnT-5|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase|lactotriaosylceramide synthase|lc(3)Cer synthase|lc3 synthase
Swissprots Q59FE3 Q8WWP9 D3DNS5 Q7L9Z5 Q9BYG0
Accessions CAC43634 CAD32047 CAD32048 EAW78333 EAW78334 EAW78335 EAW78336 Q9BYG0 AB045278 BAB40940 AB209517 BAD92754 AF368169 AAK53403 AJ304505 CAC83093 AK074235 AK074424 AK091474 BAG52370 BC028058 AAH28058 BF001695 BP270576 BU684277 DQ891070 ABM81996 DQ894252 ABM85178 XM_005247823 XP_005247880 XM_005247824 XP_005247881 XM_005247825 XP_005247882 XM_011513225 XP_011511527 XM_011513226 XP_011511528 XM_011513227 XP_011511529 XM_011513228 XP_011511530 XM_011513229 XP_011511531 NM_032047 NP_114436
Function Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus. {ECO:0000269|PubMed:11283017}.
Top Pathways Glycosphingolipid biosynthesis - lacto and neolacto series

B3GNT5-Over-expression-Lysate - LY14863a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag B3GNT5 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the B3GNT5 gene.

B3GNT5 293T Cell Transient Overexpression Lysate(Denatured) - H00084002-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

B3GNT5 overexpression lysate - LY410361 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

B3GNT5 293 Cell Lysate - 405321 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

B3GNT5 Overexpression Lysate (Native) - NBL1-07887 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: B3GNT5 Overexpression Lysate (Adult Normal) [NBL1-07887] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for B3GNT5.

B3GNT5 Over-expression Lysate Product - GWB-80E1A7 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

B3GNT5 Overexpression Lysate (Denatured) - H00084002-T03 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

B3GNT5 Overexpression Lysate (Denatured) - H00084002-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human B3GNT5 Knockdown Stable Cell Line - CSC-DC001270 from Creative biogene

Category Cell Line
Species Human
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