| Gene Symbol |
B3GNT5
|
| Entrez Gene |
84002
|
| Alt Symbol |
B3GN-T5, beta3Gn-T5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
|
| Other Description |
BGnT-5|UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5|beta 1,3 N-acetyglucosaminyltransferase Lc3 synthase|beta-1,3-Gn-T5|beta-1,3-N-acetylglucosaminyltransferase 5|beta-1,3-N-acetylglucosaminyltransferase bGnT-5|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase|lactotriaosylceramide synthase|lc(3)Cer synthase|lc3 synthase
|
| Swissprots |
Q59FE3 Q8WWP9 D3DNS5 Q7L9Z5 Q9BYG0
|
| Accessions |
CAC43634 CAD32047 CAD32048 EAW78333 EAW78334 EAW78335 EAW78336 Q9BYG0 AB045278 BAB40940 AB209517 BAD92754 AF368169 AAK53403 AJ304505 CAC83093 AK074235 AK074424 AK091474 BAG52370 BC028058 AAH28058 BF001695 BP270576 BU684277 DQ891070 ABM81996 DQ894252 ABM85178 XM_005247823 XP_005247880 XM_005247824 XP_005247881 XM_005247825 XP_005247882 XM_011513225 XP_011511527 XM_011513226 XP_011511528 XM_011513227 XP_011511529 XM_011513228 XP_011511530 XM_011513229 XP_011511531 NM_032047 NP_114436
|
| Function |
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus. {ECO:0000269|PubMed:11283017}.
|
| Top Pathways |
Glycosphingolipid biosynthesis - lacto and neolacto series
|
