MAPKAP1

Gene Symbol	MAPKAP1
Entrez Gene	79109
Alt Symbol	JC310, MIP1, SIN1, SIN1b, SIN1g
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase associated protein 1
Other Description	MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots	Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1
Accessions	EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022
Function	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location	Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue Specificity	Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPKAP1-Over-expression-Lysate - LY10612a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

MAPKAP1 overexpression lysate - LY400381 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKAP1 overexpression lysate - LY423519 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKAP1 overexpression lysate - LY423693 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MAPKAP1 overexpression lysate - LY425171 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MAPKAP1 293 Cell Lysate - 400407 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MAPKAP1 293 Cell Lysate - 409981 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Sin1/MAPKAP1 Overexpression Lysate (Native) - NBP2-06349 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Sin1/MAPKAP1 Overexpression Lysate (Native) - NBL1-12887 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MAPKAP1 Over-expression Lysate Product - GWB-C4E7E5 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

MAPKAP1 Over-expression Lysate Product - GWB-398479 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Sin1/MAPKAP1 Overexpression Lysate (Native) - NBP2-10750 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human MAPKAP1 Knockdown Stable Cell Line - CSC-DC009210 from Creative biogene Category Cell Line Species Human

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