MAPKAP1

Gene Symbol MAPKAP1
Entrez Gene 79109
Alt Symbol JC310, MIP1, SIN1, SIN1b, SIN1g
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase associated protein 1
Other Description MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1
Accessions EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue Specificity Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}.

Sin1 (D7G1A) Rabbit mAb - 12860 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7G1A
Western blot analysis of extracts from various cell lines using Sin1 (D7G1A) Rabbit mAb.

Phospho-Sin1 (Thr86) (D4U9L) Rabbit mAb - 14716 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4U9L
Western blot analysis of extracts from serum starved NIH/3T3 cells, untreated (-) or treated with insulin (150 nM, 5 min; +) or Human Insulin-like Growth Factor I (hIGF-I) #8917 (100 ng/ml, 5 min; +) in the absence (-) or presence (+) of λ phosphatase, using Phospho-Sin1 (Thr86) (D4U9L) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

MAPKAP-1 (F-3) - sc-393166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAPKAP-1 (F-3): sc-393166. Western blot analysis of MAPKAP-1 expression in human heart tissue extract.

MAPKAP-1 (K-20) - sc-48588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAPKAP-1 (K-20): sc-48588. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic and nuclear staining of glandular cells.

MAPKAP-1 (H-300) - sc-366259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAPKAP-1 (H-300): sc-366259. Western blot analysis of MAPKAP-1 expression in HeLa (A), MCF7 (B) and NIH/3T3 (C) whole cell lysates.

Anti-SIN1 antibody - ab64188 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Ab64188 (2.5ug/ml) staining human SIN1 in human brain, cortex tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-SIN1 antibody - ab116286 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SIN1 antibody (ab116286) at 1/100 dilution + MCF7 cell line lysate at 35 µg

Anti-SIN1 antibody - ab72161 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIN1 antibody (ab72161) at 2 µg/mlLane 1 : human skeletal muscle lysate Lane 2 : human skeletal muscle lysate with immunizing peptideLane 3 : mouse skeletal muscle lysate Lane 4 : rat skeletal muscle lysate

Anti-MAPKAP1 / MIP1 Antibody (aa480-510, FITC) - LS-C207217 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (aa480-510, Azide-free, HRP) - LS-C207218 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (aa480-510, PE) - LS-C207221 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody - LS-C137292 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (C-Terminus, Agarose) - LS-C291137 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (aa480-510) - LS-C329814 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (aa481-510) - LS-C164025 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MAPKAP1 Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The MAPKAP1 antibody detected the MAPKAP1 protein (arrow).

Anti-MAPKAP1 / MIP1 Antibody - LS-C333734 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HepG2 cell line, using MAPKAP1 antibody.

Anti-MAPKAP1 / MIP1 Antibody (C-Terminus) - LS-C285957 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse Sin1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:100.

Anti-MAPKAP1 / MIP1 Antibody (aa100-150) IHC-plus™ - LS-B6519 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIN1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6519 concentration 10 ug/ml.

Anti-MAPKAP1 / MIP1 Antibody (Internal) IHC-plus™ - LS-B1376 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIN1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1376 concentration 5 ug/ml.

Anti-MAPKAP1 / MIP1 Antibody (C-Terminus) - LS-C287748 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Sin1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-MAPKAP1 / MIP1 Antibody (N-Terminus) IHC-plus™ - LS-B585 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIN1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B585 concentration 5 ug/ml.

Anti-MAPKAP1 / MIP1 Antibody (C-Terminus) - LS-C72101 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (N-Terminus) - LS-C121250 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (Internal) - LS-C121251 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPKAP1 / MIP1 Antibody (aa85-102) - LS-C47276 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot ofMip1 in human heart**lysate in the 1) absence and 2) presence of immunizing peptide and in human skeletal muscle**lysate in the 3) absence and 4) presence of immunizing peptide using antibody at 0.5 ug/ml.
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