MAPKAP1

Gene Symbol	MAPKAP1
Entrez Gene	79109
Alt Symbol	JC310, MIP1, SIN1, SIN1b, SIN1g
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase associated protein 1
Other Description	MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots	Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1
Accessions	EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022
Function	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location	Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue Specificity	Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPKAP1 / MIP1 Antibody Blocking Peptide - LS-E3003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPKAP1 / MIP1 Antibody Blocking Peptide - LS-E30326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAPKAP1 / MIP1 Antibody Blocking Peptide - LS-E30327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Sin1/MAPKAP1 Protein - H00079109-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Sin1/MAPKAP1 Protein - H00079109-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Sin1/MAPKAP1 Blocking Peptide - NBP1-76777PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Sin1/MAPKAP1 Blocking Peptide - NBP1-76776PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

MAPKAP1-Antibody-C-term-Blocking-peptide - BP14132b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Sin1 Blocking Peptide - 33R-11034 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

MIP1 - H00079109-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MIP1 - H00079109-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MIP1 - H00079109-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MIP1 - H00079109-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

MIP1 - H00079109-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

MIP1 Control Peptide - AP30536CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

MIP1 Control Peptide - AP30537CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

MAPKAP1 Peptide - 4077P from ProSci Category Peptide Species Human

MAPKAP1 Peptide - 4079P from ProSci Category Peptide Species Human

MAPKAP1 fusion protein - Ag7753 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MAPKAP1, His-tagged - MAPKAP1-29583TH from Creative Biomart Category Protein Source E. coli

Recombinant human Target of rapamycin complex 2 subunit MAPKAP1 - CSB-EP857767HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1(MAPKAP1) - CSB-YP857767HU CSB-EP857767HU CSB-BP857767HU CSB-MP857767HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Sin1 Blocking Peptide - 3971BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

MAPKAP1 Protein - abx164230 from Abbexa Category Protein Species Human, Mouse, Rat

Target of rapamycin complex 2 subunit MAPKAP1, Recombinant Protein - MBS1364264 from MyBioSource Category Protein Prices $170.00, $395.00, $640.00, $1,000.00, $1,310.00, $1,530.00, $1,530.00, $2,160.00, $2,625.00, $2,625.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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