Gene Symbol | CA9 |
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Entrez Gene | 768 |
Alt Symbol | CAIX, MN |
Species | Human |
Gene Type | protein-coding |
Description | carbonic anhydrase IX |
Other Description | CA-IX|P54/58N|RCC-associated antigen G250|RCC-associated protein G250|carbonate dehydratase IX|carbonic anhydrase 9|carbonic dehydratase|membrane antigen MN|pMW1|renal cell carcinoma-associated antigen G250 |
Swissprots | Q5T4R1 Q16790 |
Accessions | CBL94025 EAW58359 Q16790 AI023541 AJ010588 CAB82444 AL554705 BC014950 AAH14950 DQ892208 ABM83134 DQ895404 ABM86330 EF122496 ABL67717 X66839 CAA47315 XM_006716869 XP_006716932 XM_006716870 XP_006716933 XR_428428 NM_001216 NP_001207 |
Function | Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. {ECO:0000269|PubMed:18703501}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. |
Tissue Specificity | Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. |
Top Pathways | Nitrogen metabolism |
CA IX CRISPR/Cas9 KO Plasmid (h) - sc-400905 from Santa Cruz Biotechnology
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CA IX HDR Plasmid (h) - sc-400905-HDR from Santa Cruz Biotechnology
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CA IX Double Nickase Plasmid (h) - sc-400905-NIC from Santa Cruz Biotechnology
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CA IX Double Nickase Plasmid (h2) - sc-400905-NIC-2 from Santa Cruz Biotechnology
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CA IX CRISPR Activation Plasmid (h) - sc-400905-ACT from Santa Cruz Biotechnology
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CA IX CRISPR Activation Plasmid (h2) - sc-400905-ACT-2 from Santa Cruz Biotechnology
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CA IX Lentiviral Activation Particles (h) - sc-400905-LAC from Santa Cruz Biotechnology
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CA IX Lentiviral Activation Particles (h2) - sc-400905-LAC-2 from Santa Cruz Biotechnology
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CA IX siRNA (h) - sc-29869 from Santa Cruz Biotechnology
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CA IX shRNA Plasmid (h) - sc-29869-SH from Santa Cruz Biotechnology
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CA IX shRNA (h) Lentiviral Particles - sc-29869-V from Santa Cruz Biotechnology
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Carbonic Anhydrase IX/CA9 RNAi - H00000768-R01 from Novus Biologicals
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MISSION® esiRNA - EHU037121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1965 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1965 from Sigma-Aldrich
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CA9 siRNA (Human) - CRH0535 from Cohesion Biosciences
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CA9 - MBS8224590 from MyBioSource
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Human CA9 siRNA - orb261037 from Biorbyt
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CA9 shRNA Plasmid (Human) - CHH0535 from Cohesion Biosciences
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